Results 51 to 60 of about 2,771,586 (165)

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

open access: yesAdvanced Science, Volume 13, Issue 56, 9 October 2026.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li   +6 more
wiley   +1 more source

A study on selective transformation of norbornadiene into fluorinated cyclopentane-fused isoxazolines

open access: yesBeilstein Journal of Organic Chemistry, 2021
This work presents an examination of the selective functionalization of norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization of commercially available norbornadiene
Zsanett Benke   +2 more
doaj   +1 more source

The synthesis and chemistry of model compounds related to fluoropolybcers [PDF]

open access: yes, 1988
The objectives of this research project were to synthesize and investigate the chemistry of model compounds related to the hexafluoropropene/vinylidene fluoride copolymer system.
Apsey, Glenn C.
core  

Controlled radical fluorination of poly(meth)acrylic acids in aqueous solution

open access: yesNature Communications, 2017
Fluorinated alkenes have very poor reactivity in copolymerizations with non-fluorinated polar monomers. Here the authors show silver-catalyzed decarboxylative radical fluorination of poly(acrylic acid) with Selectfluor in water at room temperature to ...
Yucheng Dong, Zhentao Wang, Chaozhong Li
doaj   +1 more source

Innovations in Printed Transparent Conducting Electrodes for Advanced Next‐Generation Electronics: A Comprehensive Review

open access: yesSmall, Volume 22, Issue 59, 22 October 2026.
This review highlights advances in transparent conducting electrodes for flexible wearable electronics, analyzing their optical, electrical, and mechanical properties and their prospects for sustainable, next‐generation energy devices. ABSTRACT The emergence of wearable electronics has revolutionized photophysical and electrochemical, enabling ...
Vinayak Vitthal Satale   +6 more
wiley   +1 more source

Cu-Mediated trifluoromethylation of benzyl, allyl and propargyl methanesulfonates with TMSCF3

open access: yesBeilstein Journal of Organic Chemistry, 2013
A Cu-mediated trifluoromethylation of benzyl, allyl and propargyl methanesulfonates with TMSCF3 was developed for the first time. This method offers a convenient and economical approach to various trifluoroethyl-containing compounds.
Xueliang Jiang, Feng-Ling Qing
doaj   +1 more source

Advances in the Synthesis of Fluorinated Scaffolds by Transition Metal-Catalyzed C–H Bond Activation

open access: yesCHIMIA, 2020
Thanks to the unique features of the fluorine atom and the fluorinated groups, fluorine-containing molecules are essential. Therefore, the search for new fluorinated groups as well as straightforward and original methodologies for their installation is ...
Sara Mazet   +2 more
doaj   +1 more source

Nucleophilic Trifluoromethoxylation of Acyl Chlorides: A Direct Route to Trifluoromethyl Esters

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 18, 19 September 2026.
A new method for the synthesis of the underexplored trifluoromethyl carboxylic esters using acyl chlorides as readily available feedstocks and in situ‐generated AgOCF3 from silver fluoride and the trifluoromethyl para‐toluenesulfonate has been designed. The reaction works on a large variety of aromatic and aliphatic acyl chlorides, while minimizing the
Xavier Bertrand   +3 more
wiley   +1 more source

Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

open access: yesChemistry–Methods
Owing to the unique properties of the fluorine atom, fluorinated scaffolds have become pivotal compounds in the pharmaceutical and agrochemical industries, as well as in materials science.
Marie Caldiero   +3 more
doaj   +1 more source

Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

open access: yesNature Communications, 2018
Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and ...
Chang Xu   +5 more
doaj   +1 more source

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