Results 31 to 40 of about 2,771,586 (165)

Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals

CHIMIA, 2014
Fluorinated compounds are of significant importance in various fields due to their unique chemical, physical, and biological properties. Accordingly, the incorporation of fluorine atom(s) or fluorine-containing functionalities into organic ...
Bing Gao, Chuanfa Ni, Jinbo Hu
doaj   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Enantioselective nucleophilic difluoromethylation of aromatic aldehydes with Me3SiCF2SO2Ph and PhSO2CF2H reagents catalyzed by chiral quaternary ammonium salts

Beilstein Journal of Organic Chemistry, 2008
BackgroundAlthough the nucleophilic difluoromethylation of aldehydes, ketones, and imines has been realized with PhSO2CF2H and related reagents, there are still no reports on the enantioselective nucleophilic reactions.ResultsWith a chiral quaternary ...
Chuanfa Ni, Fang Wang, Jinbo Hu
doaj   +1 more source

Organofluorine Compounds Chemistry and Applications

, 2000
In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compunds, synthetic methods of these, their roles in pharmaceutical, agrochemical and material sciences.
Yamamoto, Hisashi, Hiyama, Tamejiro
core   +1 more source

A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis [PDF]

, 2014
A titania photoredox catalysis protocol was developed for the homocoupling of C-centered radicals derived from carboxylic acids. Intermolecular reactions were generally efficient and selective, furnishing the desired dimers in good yields under mild ...
Manley, David W., Walton, John C., Walton, John C.; id_orcid   +2 more
core   +1 more source

The Recent Development of Organofluorine Chemistry in China: Asymmetric Construction of Stereogenic Trifluoromethyl-substituted Carbon Centers

CHIMIA, 2011
The stereospecific incorporation of the trifluoromethyl group into an organic compound has attracted considerable attention and significant progress has been achieved in the past decade.
Lele Wen, Qilong Shen, Long Lu
doaj   +1 more source

KPT330 improves Cas9 precision genome- and base-editing by selectively regulating mRNA nuclear export

Communications Biology, 2022
The FDA-approved anti-cancer drug, KPT330, can indirectly inhibit Cas9 by interfering with Cas9 mRNA nuclear export and help reduce off-target editing in cells.
Yan-ru Cui, Shao-jie Wang, Tiancheng Ma, Peihong Yu, Jun Chen, Taijie Guo, Genyi Meng, Biao Jiang, Jiajia Dong, Jia Liu   +9 more
doaj   +1 more source

Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent

Beilstein Journal of Organic Chemistry, 2013
An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields.
Xiao-Ping Wang, Jin-Hong Lin, Cheng-Pan Zhang, Ji-Chang Xiao, Xing Zheng   +4 more
doaj   +1 more source

Access to Uncharted (Ethoxy)difluoromethylated‐Containing Tetrahydrofurans by Hydrogenation

Chemistry – A European Journal, EarlyView.
A Pd/C‐catalyzed selective hydrogenation of (ethoxy)difluoromethylated‐containing tetrahydrofurans was achieved. Depending on the pressure of H2, a divergent process led to either cis CF2CO2Et‐containing tetrahydrofurans or valuable α,α‐difluoro‐β‐hydroxyesters, offering key fluorinated building blocks for drug discovery while keeping the CF2CO2Et ...
Thibaud Charvillat, Victor Levet, Patrick Bernardelli, Marc Daumas, Hassan Oulyadi, Muriel Sebban, Vincent Ferey, Tatiana Besset   +7 more
wiley   +1 more source

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides [PDF]

, 2007
Article number 18A convenient microwave accelerated cross-coupling procedure between aryl chlorides with a range of boronic acids has been developed. An explanation for the low reactivity of highly fluorinated boronic acids in Suzuki coupling is provided.
Matthew L. Clarke, Marcia B. France, Edward J. Milton, Jose A. Fuentes, Clarke, Matthew L., France, Marcia B., Milton, Edward J., Fuentes, José A., Roff, Geoffrey J., Geoffrey J. Roff, Clarke, Matthew L.; id_orcid   +10 more
core   +1 more source