Results 11 to 20 of about 1,384 (194)

SulfoxFluor-enabled deoxyazidation of alcohols with NaN3

Nature Communications, 2022
Azides are common moieties in chemical synthesis. Here the authors present a methodology to synthesize alkyl azides in one step from simple alcohols under mild conditions.
Junkai Guo, Xiu Wang, Chuanfa Ni, Xiaolong Wan, Jinbo Hu   +4 more
doaj   +1 more source

Separation-free Enantiodifferentiation with Chromatogram-like Output

Cell Reports Physical Science, 2020
Summary: Chromatographic-based approaches are most widely used for the analysis of enantiomers. Unambiguous results are achieved through the visualization of each enantiomer, while the separation process is often time consuming.
Yipeng Li, Lixian Wen, Huan Meng, Jinghuang Lv, Gen Luo, Yanchuan Zhao   +5 more
doaj   +1 more source

Theoretical Study on the Origin of Abnormal Regioselectivity in Ring-Opening Reaction of Hexafluoropropylene Oxide

Molecules, 2023
That nucleophiles preferentially attack at the less sterically hindered carbon of epoxides under neutral and basic conditions has been generally accepted as a fundamental rule for predicting the regioselectivity of this type of reaction.
Cui Yu, Yueqian Sang, Yao Li, Xiaosong Xue   +3 more
doaj   +1 more source

Deoxyfluorination of alcohols with 3,3-difluoro-1,2-diarylcyclopropenes

Nature Communications, 2016
Fluorination of organic molecules can dramatically change the properties and is commonly used for the synthesis of bioactive molecules. Here, the authors report the deoxyfluorination of alcohols and the selective monofluorination of diols using bench ...
Lingchun Li, Chuanfa Ni, Fei Wang, Jinbo Hu   +3 more
doaj   +1 more source

Enantioselective nickel-catalyzed dicarbofunctionalization of 3,3,3-trifluoropropene

Nature Communications, 2022
Strategies for the catalytic asymmetric synthesis of trifluoromethylated compounds remain scarce. Here, the authors report the nickel-catalyzed enantioselective dicarbofunctionalization of 3,3,3-trifluoropropene.
Yun-Ze Li, Na Rao, Lun An, Xiao-Long Wan, Yanxia Zhang, Xingang Zhang   +5 more
doaj   +1 more source

Nucleophilic arylation with tetraarylphosphonium salts

Nature Communications, 2016
Carbon based nucleophiles often are synthetically limited by the high basicity/reactivity of the starting materials. Here, the authors show that tetraarylphosphonium salts can be induced to act as C-aryl nucleophiles for the addition to carbonyls and ...
Zuyong Deng, Jin-Hong Lin, Ji-Chang Xiao
doaj   +1 more source

RESSONÂNCIA MAGNÉTICA NUCLEAR DE SUBSTÂNCIAS ORGANOFLUORADAS: UM DESAFIO NO ENSINO DE ESPECTROSCOPIA

Química Nova, 2015
Nuclear magnetic resonance is a technique that is widely used for elucidating and characterizing organic substances. Organofluorine substances have applications in many areas from drugs to liquid crystals, but their NMR spectra are often challenging due ...
Frederico Silva Castelo Branco, Bárbara V. Silva, Gabriel Freitas do Rio, Mábio João Santana, Luiz Henrique Keng Queiroz Júnior, Angelo C. Pinto, Núbia Boechat, Luciano Morais Lião   +7 more
doaj   +1 more source

Carbohydrate Physicochemical Properties: The Innate Hydrogen Bond Donating Capacities of α‐Glucoside and α‐Galactoside Alcohol Groups

Angewandte Chemie, EarlyView.
Experimental determination of the innate hydrogen bond donating capacities of the glucose and galactose non‐anomeric alcohols revealed significant variations depending on position and relative configuration, which were quantified on the pKAHY scale, relevant for MedChem purposes, hence providing another tool toward rational glycomimetic development ...
Mrinal Naskar, Zhong Wang, Krunal Patel, Branko De Baets, Anaïs Goupille, Davy Sinnaeve, Eric Renault, Jean‐Yves Le Questel, Bruno Linclau   +8 more
wiley   +2 more sources

Reagent-Controlled Highly Stereoselective Difluoromethylation: Efficient Access to Chiral α-Difluoromethylamines from Ketimines

Molecules, 2022
A reagent-controlled highly stereoselective reaction between (S)-difluoromethyl phenyl sulfoximine 1 and imines is reported, and this synthetic method provides a variety of enantiomerically enriched α-difluoromethyl amines. The main pros of this approach
Qinghe Liu, Taige Kong, Chuanfa Ni, Jinbo Hu   +3 more
doaj   +1 more source