Results 11 to 20 of about 2,771,586 (165)

Toolbox for emerging fluorinated groups [PDF]

Comptes Rendus. Chimie
Organofluorine chemistry is a research field of rapid expansion. Due to the unique properties of the fluorine atom and the fluorinated residues, innovation is required to push forward the boundaries of this very active research field by expanding the ...
Rzayev, Javid, Chang, Zhenbang, Besset, Tatiana   +2 more
doaj   +2 more sources

Direct Regioselective para-Fluorination via I(I)/I(III) Catalysis. [PDF]

Angew Chem Int Ed Engl
A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Roblick C, Bendix JD, Hilton TA, Bussmann K, Daniliuc CG, Gilmour R.   +5 more
europepmc   +3 more sources

Nickel-Catalyzed Three-Component Difluoroalkylation-Amination for the Direct Access to Anti-Inflammatory β-Difluoroalkyl Amines. [PDF]

Adv Sci (Weinh)
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Xu C, Ma F, Ding F, Wang L, Li Y, He Y, Zhang X, He S, Liu D.   +8 more
europepmc   +2 more sources

Organofluorine Chemistry: Synthesis and Applications

, 2020
Organofluorine Chemistry: Synthesis and Applications gives a comprehensive outlook on modern synthetic methodologies for organofluorine compounds.
Reddy, V. Prakash, Reddy, Prakash
core   +2 more sources

Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks [PDF]

, 2014
The authors thank EaStCHEM, the Royal Society (for a Wolfson Merit Award for D.O’H.) and CNPq and FAPESP are also gratefully acknowledged for the studentships (to R.A.C.
Rodrigo A. Cormanich (1751113), Cormanich, Rodrigo A., Rittner, Roberto, Roberto Rittner (364724), O'Hagan, David, Michael Bühl (1317231), David O’Hagan (1313640), Buehl, Michael, Buehl, Michael; id_orcid, O'Hagan, David; id_orcid   +9 more
core   +1 more source

Prins fluorination cyclisations : Preparation of 4-fluoro-pyran and -piperidine heterocycles [PDF]

, 2010
The Prins reaction was investigated using BF3 center dot OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3 center dot OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3 center dot ...
David O'Hagan, O'Hagan, David, Guillaume G. Launay, Alexandra M. Z. Slawin, Launay, Guillaume G., Slawin, Alexandra M. Z., Slawin, Alexandra M. Z.; id_orcid, O'Hagan, David; id_orcid   +7 more
core   +1 more source

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +2 more sources

Nucleophilic arylation with tetraarylphosphonium salts

Nature Communications, 2016
Carbon based nucleophiles often are synthetically limited by the high basicity/reactivity of the starting materials. Here, the authors show that tetraarylphosphonium salts can be induced to act as C-aryl nucleophiles for the addition to carbonyls and ...
Zuyong Deng, Jin-Hong Lin, Ji-Chang Xiao
doaj   +1 more source

Enantioselective nickel-catalyzed dicarbofunctionalization of 3,3,3-trifluoropropene

Nature Communications, 2022
Strategies for the catalytic asymmetric synthesis of trifluoromethylated compounds remain scarce. Here, the authors report the nickel-catalyzed enantioselective dicarbofunctionalization of 3,3,3-trifluoropropene.
Yun-Ze Li, Na Rao, Lun An, Xiao-Long Wan, Yanxia Zhang, Xingang Zhang   +5 more
doaj   +1 more source

RESSONÂNCIA MAGNÉTICA NUCLEAR DE SUBSTÂNCIAS ORGANOFLUORADAS: UM DESAFIO NO ENSINO DE ESPECTROSCOPIA

Química Nova, 2015
Nuclear magnetic resonance is a technique that is widely used for elucidating and characterizing organic substances. Organofluorine substances have applications in many areas from drugs to liquid crystals, but their NMR spectra are often challenging due ...
Frederico Silva Castelo Branco, Bárbara V. Silva, Gabriel Freitas do Rio, Mábio João Santana, Luiz Henrique Keng Queiroz Júnior, Angelo C. Pinto, Núbia Boechat, Luciano Morais Lião   +7 more
doaj   +1 more source