Results 21 to 30 of about 1,384 (194)
Angewandte Chemie, EarlyView.A robust and efficient method to access diversely functionalized fluorinated piperidines was developed. The approach features the hydrogenation of polysubstituted pyridines bearing CF3, CF2H, and CF2CO2Et substituents using an inexpensive, readily available heterogeneous Pd/C catalyst under air‐ and moisture‐tolerant conditions, offering an appealing ...
Thibaud Charvillat +7 more
wiley +2 more sources
Nickel-catalyzed alkyl-arylation of 3,3,3-trifluoropropene
Communications Chemistry, 2022 3,3,3-Trifluoropropene is a cost-efficient precursor for the preparation of trifluoromethylated compounds, but limited methods for its efficient transformation have been reported.
Chang Xu +3 more
doaj +1 more source
Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis
Angewandte Chemie, EarlyView.A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick +5 more
wiley +2 more sources
Oxidation of difluorocarbene and subsequent trifluoromethoxylation
Nature Communications, 2019 Difluorocarbene is a versatile and efficient intermediate for fluorine incorporation. Here, the authors show that difluorocarbene can be oxidized to carbonyl fluoride and this process is confirmed in 18O-trifluoromethoxylation reactions, by observation ...
Jiao Yu +4 more
doaj +1 more source
Organofluorine Chemistry: Taking the Next Steps [PDF]
Advanced Synthesis & Catalysis, 2010 Antonio Togni
openaire +2 more sources
Beilstein Journal of Organic Chemistry, 2014 Background: 1,1-Difluoroalkenes cannot only be used as valuable precursors for organic synthesis, but also act as bioisosteres for enzyme inhibitors. Among various methods for their preparation, the carbonyl olefination with difluoromethylene phosphonium
Fei Wang +3 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2023 A visible-light-induced nickel-catalyzed cross coupling of alkyl carboxylic acids with N-trifluoroethoxyphthalimide is described. Under purple light irradiation, an α-hydroxytrifluoroethyl radical generated from a photoactive electron donor–acceptor ...
Feng Chen +4 more
doaj +1 more source
Flow microreactor synthesis in organo-fluorine chemistry
Beilstein Journal of Organic Chemistry, 2013 Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties.
Hideki Amii +2 more
doaj +1 more source
Prins fluorination cyclisations : Preparation of 4-fluoro-pyran and -piperidine heterocycles
, 2010 The Prins reaction was investigated using BF3 center dot OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3 center dot OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3 center dot ...
David O'Hagan +5 more
core +1 more source
Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals
CHIMIA, 2014 Fluorinated compounds are of significant importance in various fields due to their unique chemical, physical, and biological properties. Accordingly, the incorporation of fluorine atom(s) or fluorine-containing functionalities into organic ...
Bing Gao, Chuanfa Ni, Jinbo Hu
doaj +1 more source