Results 241 to 250 of about 2,401,578 (298)

Advances in organoid imaging and automated morphometric analysis: from optical microscopy to computational approaches. [PDF]

Front Cell Dev Biol
Zubova AV, Simkin IV, Shumilin RV, Lifanov DA, Perepelitsa ES, Sokolov MS, Kryuchkov NP, Yurchenko SO, Salmina AB, Illarioshkin SN.   +9 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

The Organoid Decade: Leveraging 3D Patient-Derived Organoids to Bridge the Translational Gap in Triple-Negative Breast Cancer: A Systematic Review. [PDF]

Cells
Sani J, Yi B, Xi Y.
europepmc   +1 more source

Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Crohn's disease (CD) is a multifactorial inflammatory bowel disease (IBD) characterized by impaired epithelial barrier integrity, excessive immune hyperactivation, and gut microbiota perturbations. Cumulative evidence supports the role of the intestinal epithelial barrier, immune system and gut microbiota in the progression of CD ...
Qing Lai, Qing‐Yun Zhang, Wei‐Peng Yang, Chun‐Ying Luo   +3 more
wiley   +1 more source

Recent advances and expanding applications of organoid models in unveiling drug ADME profiles. [PDF]

J Pharm Anal
Zhang G, Zhang R, Shu Z, Zhao J, Yin L, Shi M, Han Y.   +6 more
europepmc   +1 more source

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Heparin augments EV yield in culture by inhibiting EV binding to cell‐surface HSPG and masking EV surface. Preventing autocrine and homotypic paracrine EV uptake during cell culture results in EV accumulation and higher yield. Heparin improved EV recovery after storage in NaCl but not in complex media or protein‐rich buffer(Please see Figure 9 for ...
André Cronemberger Andrade, Rodolphe Poupardin, Martin Wolf, Liliia Paniushkina, Karim Selmi, Deepika Kundully Suresh, Nicole Maeding, Heide‐Marie Binder, Janine Zwicklhuber, Sarah Hochmann, André Görgens, Samir El Andaloussi, Katharina Schallmoser, Dirk Strunk   +13 more
wiley   +1 more source

LRRC32 Mediates Resistance to Everolimus in Hormone Receptor-Positive, HER2-Negative Breast Cancer. [PDF]

Cancer Manag Res
Wang L, Chen X, Li X, Wang Y, Shen R.
europepmc   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source