Results 1 to 10 of about 118 (103)
Evaluation of canine epidermis and keratinocytoids (keratinocytic organoids) by transmission electron microscopy. [PDF]
Vet DermatolBackground – Skin disease is a common complaint in veterinary medicine. Current models often use live animals. Epidermal organoids (keratinocytoids) are 3D miniature organs created in culture from single epidermal keratinocytes. These keratinocytoids can be used as an alternative to live animal studies to investigate epidermal structures and skin ...
Lui CC +5 more
europepmc +2 more sources
DECORIN, a triceps-derived myokine, protects sorted β-cells and human islets against chronic inflammation associated with type 2 diabetes. [PDF]
Acta Physiol (Oxf)Abstract Aim Pancreatic β‐cells are susceptible to inflammation, leading to decreased insulin production/secretion and cell death. Previously, we have identified a novel triceps‐derived myokine, DECORIN, which plays a pivotal role in skeletal muscle‐to‐pancreas interorgan communication.
Langlois A +11 more
europepmc +2 more sources
Medizinrecht, 2020 Organoids are developed from stem cells and serve as three-dimensional model systems for different organs. They have great potential for research and medicine, but also raise philosophical, ethical and legal questions which have rarely been discussed in Germany so far.
exaly +6 more sources
Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Review on the Vascularization of Organoids and Organoids-on-a-Chip [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The use of human cells for the construction of 3D organ models in vitro based on cell self-assembly and engineering design has recently increased in popularity in the field of biological science. Although the organoids are able to simulate the structures and functions of organs in vitro, the 3D models have difficulty in forming a complex vascular ...
Xingli Zhao +10 more
openaire +3 more sources
Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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Modelos tridimensionais de cultura de células: aproximando o in vitro do in vivo
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Os avanços biotecnológicos em associação com a pressão para substituir a experimentação animal impulsionam o desenvolvimento de modelos in vitro mais fisiológicos e preditivos da resposta in vivo.
Marianna Cavalheiro da Costa +3 more
doaj +7 more sources
Organoids and Colorectal Cancer [PDF]
Cancers, 2021 Organoids were first established as a three-dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC)
Antonio Barbáchano +6 more
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Nevo Sebáceo de Jadassohn Facial: Uma Apresentação Exuberante
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2020 O nevo sebáceo de Jadassohn (NSJ) é um hamartoma organoide da pele usualmente observado ao nascimento ou logo após. A localização mais comum é o couro cabeludo, no entanto, pode envolver outras áreas da cabeça e pescoço.
Carolina Fernandes Pereira +3 more
doaj +1 more source
Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
openaire +2 more sources