Results 21 to 30 of about 588 (133)
Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACT Over the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank [PDF]
Frontiers in Oncology, 2021 Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that stably retain key characteristics of the respective organs. Organoids can be generated from healthy or pathological tissues derived from patients. Cancer organoid culture platforms have several advantages, including conservation of the cellular composition ...
Zilong Zhou, Lele Cong, Xianling Cong
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Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
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Lungen-Organoide bringen neuen Schwung in die COPD-Forschung
BIOspektrumChronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and a systemic chronic inflammatory disease. It is caused by factors such as aging and environmental pollution, and characterized by a dysfunction of the ...
Lili Rusznyak +2 more
semanticscholar +1 more source
DNA-basierte Mikrokugeln als innovative Steuerungstechnologie für Organoide
BIOspektrumOrganoids are powerful organ models for studying tissue development and disease, yet their structural and functional complexity remains limited due to the lack of controlled biochemical signaling.
Cassian Afting +3 more
semanticscholar +1 more source
Padronização de cultura organoide para avaliação da melanogênese induzida por UVB, UVA e luz visível
Anais Brasileiros de Dermatologia (Versão em Português), 2020 a Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil b Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil c Programa de Pós-Graduação ...
Thainá Oliveira Felicio Olivatti +4 more
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Life Science Alliance, 2022 Over the last decades, organoids have been established from most of the tissue-resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalised medicine. In recent years, several reports hinted at intraculture organoid variability, but a systematic analysis
Kristin Gehling +6 more
openaire +3 more sources
Alveolen-on-Chip: Organoide treffen Organ-on-Chip
BIOspektrumWe present a novel Alveoli-on-Chip (AOC) platform that combines patient-derived organoids with organ-on-chip technology. Primary human lung cells isolated from surgical resections are expanded as organoids – creating a renewable, well-characterized ...
J. Schulte +4 more
semanticscholar +1 more source
Organoid Medicine in Hepatology [PDF]
Clinical Liver Disease, 2020 Answer questions and earn https://www.wileyhealthlearning.com/Activity/7025323/disclaimerspopup.aspx.
Kokoro Sakabe +2 more
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Organoid-derived extracellular vesicles: From organoid, to organoid
Organoid ResearchOrganoids are miniature, three-dimensional tissue constructs generated from stem cells or primary cells that recapitulate key structural and functional features similar to those of in situ organs. Extracellular vesicles (EVs) are non-replicating nanocarriers enclosed by a phospholipid bilayer (20–400 nm) that mediate the delivery of bioactive
Ting Cheng +3 more
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