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Organoids are not organs: Sources of variation and misinformation in organoid biology
Stem Cell Reports, 2023 In the past decade, the term organoid has moved from obscurity to common use to describe a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of the in vivo organ it models. The term organoid is now applied to structures formed as a result of two distinct processes: the capacity for adult epithelial stem cells ...
Kim Bak Jensen, Melissa Helen Little
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Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
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, 2022 The epithelial layer of the gastrointestinal (GI) tract provides a barrier between the environment and the body. Dysfunction of the epithelium, including changes of the innate immune response facilitated by pattern recognition receptors (PRRs), plays a ...
Kayisoglu-Kaya, Özge
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Diseño de dispositivo para estimulación mecánica de organoide óseo
, 2023 El campo de la ingeniería está ligado al campo de la salud proporcionándole diversas herramientas para sus investigaciones y avances. El interés de este trabajo reside en la estimulación mecánica celular.
Martín Agüera, Carmen
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACT Over the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Endomeetriumi organoidide tekitamine ning peptiid-suunatud nanopartiklite sisenemine [PDF]
, 2023 Endomeetriumi uurimiseks kasutatakse sageli 2D rakukultuure, mis ei ole aga hormonaalselt mõjutatavad ning seega võivad olla ebapiisavad. Lahendusena on võimalik kasutada 3D kultuure, näiteks organoide, mis on oma loomult eluskoele sarnasemad ...
Paet, Sylvia
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Science, 2019 Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for ...
Sunghee Estelle Park +2 more
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Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank [PDF]
Frontiers in Oncology, 2021 Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that stably retain key characteristics of the respective organs. Organoids can be generated from healthy or pathological tissues derived from patients. Cancer organoid culture platforms have several advantages, including conservation of the cellular composition ...
Zilong Zhou, Lele Cong, Xianling Cong
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, 2020 El presente trabajo de Investigación-Creación tiene como intención dar cuenta de las múltiples posibilidades del Cadáver Exquisito y de la Escritura Automática: Organoide Cadámatico, en donde estas nociones se convierten en excusa de composición ...
Díaz Morales, Natalia Carolina
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, 2021 In ihrem Sachstandsbericht geben Martin Zenke und Sina Bartfeld einen Überblick über gegenwärtige Entwicklungen der Stammzell- und Organoidforschung. Stammzellen werden definiert als Zellen, die sich sowohl vermehren als auch spezialisierte Zelltypen ...
Bartfeld, Sina, Zenke, Martin
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