Results 11 to 20 of about 557 (139)
Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Review on the Vascularization of Organoids and Organoids-on-a-Chip [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The use of human cells for the construction of 3D organ models in vitro based on cell self-assembly and engineering design has recently increased in popularity in the field of biological science. Although the organoids are able to simulate the structures and functions of organs
Xingli Zhao +10 more
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Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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Morphologische Charakterisierung renaler Organoide aus humanen induzierten pluripotenten Stammzellen [PDF]
, 2023 Die steigende Zahl chronisch Nierenkranker erfordert die tiefergehende Analyse der renalen Pathophysiologie und die Entwicklung neuer therapeutischer Strategien. Hierfür wird ein möglichst exaktes Modell der Niere benötigt.
Rutten, Lena
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Modellierung von Aktin-assoziierten kortikalen Malformationen in zerebralen Organoiden [PDF]
, 2023 Hintergrund: Das Baraitser-Winter-Zerebro-Fronto-Faziale-Syndrom (BWCFF-S) gehört mit einer Prävalenz von 1:1.000.000 zu den sehr seltenen genetischen Krankheiten und wird durch Missense-Mutationen in den Genen ACTB und ACTG1, die die zytoplasmatischen ...
Niehaus, Indra
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Organoids and Colorectal Cancer [PDF]
Cancers, 2021 Organoids were first established as a three-dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC)
Antonio Barbáchano +6 more
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Mikrosatelliteninstabilität in Organoiden aus murinen intestinalen Stammzellen unter Msh2-Defizienz [PDF]
, 2022 Kurzreferat Unter mismatch repair-Defizienz (MMR-D) akkumulieren Mutationen durch die Fehlfunktion eines betroffenen MMR-Gens in Abhängigkeit von der Zeit und können zum Auftreten von kolorektalen Karzinomen (CRC) führen.
Kreutzmann, Tobias
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
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Organoide : ein wesentliches Element in einem generativen Modellgefüge ; übersetzt von Anja Pichl
, 2021 In diesem wissenschaftstheoretischen Beitrag geht es um Organoide als wissenschaftliche ...
Fagan, Melinda Bonnie
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