Results 11 to 20 of about 96 (84)
Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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DECORIN, a triceps-derived myokine, protects sorted β-cells and human islets against chronic inflammation associated with type 2 diabetes. [PDF]
Acta Physiol (Oxf)Abstract Aim Pancreatic β‐cells are susceptible to inflammation, leading to decreased insulin production/secretion and cell death. Previously, we have identified a novel triceps‐derived myokine, DECORIN, which plays a pivotal role in skeletal muscle‐to‐pancreas interorgan communication.
Langlois A +11 more
europepmc +2 more sources
Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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Die Linienmuster der Haut und ihre Dermatosen
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 4, Page 341-365, April 2020., 2020 Zusammenfassung Die Kenntnis der Linienmuster der Haut stellt eine Schlüsselkompetenz für jeden Dermatologen dar. Vier Hauptgruppen von Linienmustern sind relevant: Langer‐Linien, Dermatome, Blaschko‐Linien und exogene Muster. Die Langer‐Linien markieren die Richtung der geringsten Spannung der Haut und sind diagnostisch wichtig für einige ...
Sonja Senner +3 more
wiley +1 more source
Bioengineering, 2023 Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature
Hannah A. Strobel +2 more
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Organoid assessment technologies
Clinical and Translational Medicine, 2023 AbstractDespite enormous advances in the generation of organoids, robust and stable protocols of organoids are still a major challenge to researchers. Research for assessing structures of organoids and the evaluations of their functions on in vitro or in vivo is often limited by precision strategies. A growing interest in assessing organoids has arisen,
Yuyuan Gu +5 more
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BJS (British Journal of Surgery), Volume 106, Issue 10, Page 1404-1414, September 2019., 2019 Organoid technology was used to create a preclinical model for evaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases from colorectal cancer. Current HIPEC regimens were tested and a novel rational treatment combination of mitomycin C with inhibitors of ATR was investigated.
I. Ubink +13 more
wiley +1 more source
Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
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