Results 11 to 20 of about 929 (130)
Medizinrecht, 2020 Zusammenfassung Organoide sind dreidimensionale, aus Stammzellen entwickelte Modellsysteme für unterschiedliche Organe, die großes Potenzial für Forschung und Medizin bergen.
Alev, Cantas +6 more
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Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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Organoides de cérebro como modelos de doenças de Alzheimer e Parkinson: uma revisão narrativa sobre as perspectivas para medicina regenerativa e personalizada [PDF]
, 2023 Há muitos anos a cultura celular bidimensional (2D) é utilizada como modelo de estudo de doenças, possuindo grande importância na medicina regenerativa, apesar de ainda conter limitações significativas.
Marques, Bruno Lemes +6 more
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Etablierung eines patientenabgeleiteten 3D-Tumormodells für Brustkrebspatientinnen [PDF]
, 2023 Die Organoidtechnologie birgt viele Vorteile gegenüber anderen Mammakarzinom-Kulturmodellen und stellt einen viel beforschten Hoffnungsträger für die personalisierte Therapie dieser vielseitigen Krankheitsentität dar.
Wagner, Anna
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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Charakterisierung von Organoidkulturen aus Endometrium bei unterschiedlichen Indikationen zu einer operativen Therapie [PDF]
, 2022 Die Technologie der Zellkultivierung hat durch die Etablierung dreidimensionaler Zellkulturen große Fortschritte gemacht. Die sogenannten Organoide entstehen u.a.
Kern (geb. Martin), Lilija
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Ethics and regulation of neuronal optogenetics in the European Union [PDF]
, 2023 Neuronal optogenetics is a technique to control the activity of neurons with light. This is achieved by artificial expression of light-sensitive ion channels in the target cells.
Faltus, Timo +3 more
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Morphologische Charakterisierung renaler Organoide aus humanen induzierten pluripotenten Stammzellen [PDF]
, 2023 Die steigende Zahl chronisch Nierenkranker erfordert die tiefergehende Analyse der renalen Pathophysiologie und die Entwicklung neuer therapeutischer Strategien. Hierfür wird ein möglichst exaktes Modell der Niere benötigt.
Rutten, Lena
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