Results 291 to 300 of about 112,967 (355)

Fully defined matrices for the culture and expansion of intestinal stem cells and organoids

, 2016
Lutolf Matthias, Nikolce Gjorevski
openalex   +1 more source

Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury

Advanced Science, EarlyView.
A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton, Victoria Marsh Durban, Riccardo Barrile, Michael A. Helmrath, Takanori Takebe, Adrian Roth, Magdalena Kasendra   +11 more
wiley   +1 more source

Hypoxia and Multilineage Communication in 3D Organoids for Human Disease Modeling. [PDF]

Biomimetics (Basel)
Ehab S, Gaser OA, Dayem AA.
europepmc   +1 more source

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

Advanced Science, EarlyView.
A multi‐agent AI (AI co‐scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti‐fibrotic efficacy and toxicity of these drugs is assessed in multi‐lineage human hepatic organoids grown in microwells (microHOs).
Yuan Guan, Lu Cui, Jakkapong Inchai, Zhuoqing Fang, Jacky Law, Alberto Alonzo Garcia Brito, Annalisa Pawlosky, Juraj Gottweis, Alexander Daryin, Artiom Myaskovsky, Lakshmi Ramakrishnan, Anil Palepu, Kavita Kulkarni, Wei‐Hung Weng, Zhuanfen Cheng, Vivek Natarajan, Alan Karthikesalingam, Keran Rong, Yunhan Xu, Tao Tu, Gary Peltz   +20 more
wiley   +1 more source

Accelerated maturation of branched organoids confined in collagen droplets.

Lab Chip
Ruider I, Pastucha A, Raich MK, Xu W, Liu Y, Reichert M, Weitz D, Bausch AR.   +7 more
europepmc   +1 more source

Organoids: physiologically relevant <i>ex vivo</i> models for viral disease research. [PDF]

J Virol
Wang Y, Peng D, Li M, Yao M, Li T, Li S, Qiu H-J, Li L-F.   +7 more
europepmc   +1 more source

Secondary Bile Acids Modified by Odoribacter Splanchnicus Alleviate Colitis by Suppressing Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
In ulcerative colitis, the loss of Odoribacter splanchnicus disrupts a microbiota‐metabolite‐neutrophil axis. Restoring this bacterium boosts lithocholic acid, which suppress neutrophil extracellular trap formation and eases colonic inflammation.
Jing Xu, Jianhong Li, Xue Guo, Chen Huang, Yao Peng, Haoming Xu, Yingfei Li, Jingkui Xu, Jinxia Hu, Yitong Liao, Yuqiang Nie, Youlian Zhou   +11 more
wiley   +1 more source

Recent advances in applications of nanoparticles and decellularized ECM for organoid engineering. [PDF]

Mater Today Bio
Lee SJ, Cho JY, Heo TH, Yang DH, Chun HJ, Yoon JK, Jeong GJ.   +6 more
europepmc   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

Endometrial cancer progression driven by PTEN-deficiency requires miR-424(322)^~503. [PDF]

Cell Death Dis
Vidal-Sabanés M, Bonifaci N, Navaridas R, Egea J, Encinas M, Rodriguez-Barrueco R, Silva JM, Matias-Guiu X, Llobet-Navas D, Dolcet X.   +9 more
europepmc   +1 more source