Results 291 to 300 of about 120,310 (351)

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Single-cell sequencing and organoids: applications in organ development and disease. [PDF]

Mol Biomed
Li T, Yin J, Hao Y, Gao W, Li Q, Feng Q, Tao B, Hao M, Liu Y, Lin C, Wang D.   +10 more
europepmc   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenke, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Salivary gland organoids and the future of modeling autoimmune epithelitis in Sjögren’s disease

Ting Yang, Negaar Goudarzi, Frans G. M. Kroese, Xavier Mariette, Sarah Pringle, Gaëtane Nocturne   +5 more
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Established and emerging new approach methodologies in neuroscience. [PDF]

Front Neurosci
Imberechts D, Ny A, Copmans D.
europepmc   +1 more source

Time evolution of the organoid growth process.

Sakurako Tanida (22076056), Kana Fuji (22076059), Linjie Lu (7180379), Tristan Guyomar (22076062), Byung Ho Lee (2685499), Alf Honigmann (1661323), Anne Grapin-Botton (186660), Daniel Riveline (371781), Tetsuya Hiraiwa (9192386), Makiko Nonomura (325442), Masaki Sano (269338)   +10 more
openalex   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Protocol for modeling the repair of intestinal damage by co-culturing mesenchymal stromal/stem cells and intestinal organoids. [PDF]

STAR Protoc
Skarp KP, Yetkin-Arik B, Jansen SA, Lindemans CA, Lorenowicz MJ.   +4 more
europepmc   +1 more source

Table 1_Establishment and transcriptomic characterization of canine organoids from multiple tissues.xlsx

Christopher Zdyrski (11516168), Vojtech Gabriel (14055582), Oscar Ospina (133505), Hannah F. Nicholson (22674764), Michael Catucci (22674767), Bryan J. Melvin (22674770), Hannah Wickham (14055579), Dipak Kumar Sahoo (9134166), Kimberly Dao (15196324), Leeann S. Aguilar Meza (22674773), Abigail Ralston (14662223), Leila Bedos (14055576), William Bastian (18419889), Sydney Honold (14662229), Pablo Piñeyro (426131), Aleksandra Pawlak (378248), Megan P. Corbett (13103032), Eugene F. Douglass (1371312), Karin Allenspach (335040), Jonathan P. Mochel (6102389)   +19 more
openalex   +1 more source