Results 301 to 310 of about 120,310 (351)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Epithelial WNT secretion drives niche escape of developing gastric cancer. [PDF]

Mol Cancer
Lee J, Kim S, Oh Y, Jahn SR, Kim J, Kim Y, Schmäche T, Kim SM, Teriyapirom I, Groß T, Kwon O, Kim J, Kim S, Ada AM, Català-Bordes A, Cho Y, Kim J, Andersson-Rolf A, Merker SR, Lim JY, Park JY, Klompstra TM, Yoon KJ, Lim DS, Lee HS, Kim JK, Choi E, Goldenring JR, Cheong JH, Kim H, Stange DE, Lee H, Koo BK, Lee JH.   +33 more
europepmc   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Building global research equity through lung organoids: a prerequisite for the next respiratory pandemic. [PDF]

Front Med (Lausanne)
Hossain MK, Kim HR.
europepmc   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Tropism, replication competence, and cellular responses of HAdV-14p1 in human airway organoids. [PDF]

iScience
Guo W, Yang Y, Liang Y, Cui F, Li L, Peng X, Zhou J, Li Y, Deng Y, Wang Y, Chen R, Wen T, Lin C, Lin W, Liu L, Lin Y, Chen Q.   +16 more
europepmc   +1 more source

NICI organoid culture bank with 90 organoids

AMC will deliver 3 samples from 30 patients (patientderived oesophageal and pancreatic cancer organoids from an existing organoid culture bank covering the entire spectrum of tumour heterogeneity) to prof Burgering (UMCU). A report will be written on the establishment of the organoid culture bank.
openaire   +1 more source

Evaluating carboplatin and PARP inhibitor combination efficacy using high-grade serous carcinoma spheroids and organoids. [PDF]

Cancer Biol Ther
Tomas EJ, Davis J, Ramos Valdes Y, Shepherd TG.   +3 more
europepmc   +1 more source

Application and challenges of tumor organoid technology in precision immunotherapy. [PDF]

Front Immunol
Zhao X, Gao J, Liu Y, Shi Y, Zhang M, Zhang C, Chen J.   +6 more
europepmc   +1 more source

Artificial Intelligence Virtual Organoids (AIVOs). [PDF]

Bioact Mater
Bai L, Su J.
europepmc   +1 more source