Results 311 to 320 of about 112,967 (355)

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Single-cell atlas of cervical organoids uncovers epithelial immune heterogeneity and intercellular cross-talk during Chlamydia infection. [PDF]

Sci Adv
Prakash PG, Kumar N, Koster S, Wentland C, Dhanraj J, Gurumuthy RK, Chumduri C.   +6 more
europepmc   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Liver-bone organoids reveal senescence-driven interorgan crosstalk. [PDF]

Bioact Mater
Zhang Y, Li Y, Wang F, Dong Z, Wang J, Chen Y, Fu Y, Lu Y, Bao X, Lai Y, Jing Y, Wang J, Peng J, Lin CP, Su J, He M.   +15 more
europepmc   +1 more source

3D bioprinting bone/cartilage organoids: construction, applications, and challenges. [PDF]

J Orthop Translat
Gao D, Li R, Pan J, Li C, Zhang W, Qin L, Lai Y.   +6 more
europepmc   +1 more source

Species-specific basal fluidization shapes early forebrain development

Xu S, Li G, Wilsch-Bräuninger M, Trivedi V, Campàs O, Ebisuya M.   +5 more
europepmc   +1 more source

The emergence of electrical activity in human brain organoids. [PDF]

Stem Cell Reports
Mancinelli S, Bariselli S, Lodato S.
europepmc   +1 more source

Radiation-Induced EMT of Adipose-Derived Stem Cells in 3D Organotypic Culture via Notch Signaling Pathway. [PDF]

Biology (Basel)
Choi SJ, Kim M, Chung KT, Son TG.
europepmc   +1 more source

Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy. [PDF]

Proc Natl Acad Sci U S A
Wan Z, Li C, Zhou Y, Yu Y, Chiu MC, Huang J, Zhang S, Zhu X, Lan Q, Deng Y, Xue W, Jiang C, Wu J, Zhao Z, Cai JP, Huang L, Zhang Y, Liu X, Zhang Z, Chu H, Zhang L, Chen Z, To KK, Yuen KY, Clevers H, Zhou J.   +25 more
europepmc   +1 more source

BEST4/CA7⁺ and goblet cells are interdependent regulators of intestinal mucus homeostasis

Spoelstra WK, Wang D, van Es JH, Clevers H, van Zon JS, Tans SJ.   +5 more
europepmc   +1 more source