Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II). [PDF]
Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement.
Cheng B +4 more
europepmc +4 more sources
New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase. [PDF]
Anthropogenic practices and recycling in the environment through natural processes result in release of potentially harmful levels of mercury into the biosphere. Mercury, especially organic forms, accumulates in the food chain.
Bridges CC +7 more
europepmc +2 more sources
Synthesis, Topological, and Biological Studies of a Novel One-Dimensional Hg(II) Coordination Polymer With Antibacterial and Anticancer Potentials. [PDF]
A novel one‐dimensional mercury coordination polymer (CP), identified as [(μ2‐Cl)(Ina)Hg(μ3‐Cl)Hg(μ2‐Cl)2(Ina)]n (1) (where Ina represents isonicotinic acid or 4‐pyridinecarboxylic acid), was synthesized via the interaction of isonicotinic acid with mercury(II) salt.
Alaei S +7 more
europepmc +2 more sources
Astatine-211-Towards In Vivo Stable Astatine-211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications. [PDF]
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Müller M +5 more
europepmc +2 more sources
Eco-Friendly and Ready-To-Market Polyurethanes: A Design of Experiment-Guided Substitution of Toxic Catalyst and Fossil-Based Isocyanate. [PDF]
Increasing bio‐based and circular components in polyurethane formulation up to 65 %w/w maintaining the market acceptability through multivariate analysis approach Abstract In this contribution, we tackle the replacement of the Hg‐based catalyst and fossil‐derived isocyanate precursors toward the formulation of a more sustainable polyurethane ...
Viada G +5 more
europepmc +2 more sources
The biotransformation of organomercury compounds. [PDF]
Daniel JW.
europepmc +4 more sources
Glutathione reductase plays a role in the metabolism of methylmercury degradation in Rhodotorula mucilaginosa. [PDF]
Mercury pollution is a kind of heavy metal pollution with great harm and strong toxicity which exists worldwide. Some microorganisms can convert highly toxic methylmercury into inorganic mercury compounds with significantly reduced toxicity.
Guo Y +8 more
europepmc +2 more sources
Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea. [PDF]
Mercury (Hg) is a highly toxic element due to its high affinity for protein sulfhydryl groups, which upon binding, can destabilize protein structure and decrease enzyme activity.
Christakis CA, Barkay T, Boyd ES.
europepmc +2 more sources
The current study aimed to prepare new organomercury and organotellurium compounds based on the condensation reaction of 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (camphor) and p-aminophenyl mercuric(II) chloride.
Nuha Hussain Al-Saadawy
doaj +1 more source
The aim of the current study is to prepare organomercury and organotellurium compounds containing amino groups such as [1,1'-biphenyl]-4-amine and their derivatives by a mercuriation reaction.
Gofran Safi Mokhtar +1 more
doaj +1 more source

