Results 31 to 40 of about 623 (115)

Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons

Advanced Science, Volume 11, Issue 12, March 27, 2024.
Using human induced pluripotent stem cell (hiPSC)‐derived neurons and postmortem human Alzheimer's disease (AD) brains, the current study links aberrant S‐nitrosylation of tricarboxylic acid (TCA) cycle enzymes to a block in the TCA cycle, compromising energy production.
Alexander Y. Andreyev, Hongmei Yang, Paschalis‐Thomas Doulias, Nima Dolatabadi, Xu Zhang, Melissa Luevanos, Mayra Blanco, Christine Baal, Ivan Putra, Tomohiro Nakamura, Harry Ischiropoulos, Steven R. Tannenbaum, Stuart A. Lipton   +12 more
wiley   +1 more source

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Clinical and Translational Medicine, Volume 14, Issue 3, March 2024.
The lactate‐induced lactylation of histone lysine residues bridges the metabolic reprogramming and epigenetic rewiring. Histone lactylation fuels oncogene overexpression, expediting tumour progression and development. Targeting lactate signalling exhibits with therapeutic efficacy in diversified cancers. Abstract Heightened lactate production in cancer
Yu Zhang, Hang Song, Meili Li, Peirong Lu   +3 more
wiley   +1 more source

Unusual Manifestation of Mercuric Chloride Poisoning as Intratubular Nephrocalcinosis - A Rare Case Report. [PDF]

Indian J Nephrol, 2023
Erukkambattu J, Sharma T, Atlani M, Kapoor N.   +3 more
europepmc   +1 more source

A decacationic ferrocene-based metallostar. [PDF]

Chem Sci, 2023
Rupf SM, Moshtaha AL, Malischewski M.
europepmc   +1 more source

Organomercury Nucleic Acids: Past, Present and Future. [PDF]

Chembiochem, 2021
Ukale D, Lönnberg T.
europepmc   +1 more source

New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase. [PDF]

Arch Biochem Biophys, 2012
Bridges CC, Krasnikov BF, Joshee L, Pinto JT, Hallen A, Li J, Zalups RK, Cooper AJ.   +7 more
europepmc   +1 more source

Cleavage of an RNA Model Compound by an Arylmercury Complex. [PDF]

Chembiochem, 2021
Saleh LY, Ora M, Lönnberg T.
europepmc   +1 more source

Heavy metal resistance in the Yanomami and Tunapuco microbiome. [PDF]

Mem Inst Oswaldo Cruz, 2023
Conteville LC, Oliveira-Ferreira J, Vicente ACP.   +2 more
europepmc   +1 more source

Demethylation-The Other Side of the Mercury Methylation Coin: A Critical Review. [PDF]

ACS Environ Au, 2022
Barkay T, Gu B.
europepmc   +1 more source

Tenfold Metalation of Ferrocene: Synthesis, Structures, and Metallophilic Interactions in FeC₁₀ (HgX)₁₀. [PDF]

Chemistry, 2021
Rupf SM, Schröder G, Sievers R, Malischewski M.   +3 more
europepmc   +1 more source