Results 211 to 220 of about 34,308 (272)

The Pathogenesis of Organophosphate Polyneuropathy

Critical Reviews in Toxicology, 1992
This review discusses the facts regarding organophosphate-induced delayed polyneuropathy (OPIDP) as they are related to its pathogenesis rather than being a comprehensive review of all available data. Neuropathy target esterase (NTE) is considered to be the molecular target for OPIDP which is affected by several esterase inhibitors. Such inhibitors are
M Lotti, Marcello Lotti
exaly   +3 more sources

Organophosphates and the Heart

Chest, 1993
(Chest 1993; 103:576-82) O rganophosphates are widely used as agricultural pesticides, and some of these compounds serve as nerve agents for chemical warfare. They act as powerful inhibitors of acetyicholinesterase, resulting in accumulation of acetylcholine and overstimulation ofcholinergic synapses in the central nervous system, somatic nerves ...
A, Roth   +3 more
openaire   +2 more sources

Organophosphate Poisoning

Seminars in Neurology, 2004
Organophosphates are commonly used as pesticides around the world. Exposures to organophosphates cause a significant number of poisonings and deaths each year. Organophosphates bind and inhibit cholinesterase enzymes. Acute toxicity manifests as a cholinergic crisis with excessive glandular secretions, altered mental status, and weakness.
Daniel E, Rusyniak, Kristine A, Nañagas
openaire   +2 more sources

Organophosphate poisoning

Annals of Emergency Medicine, 1987
Organophosphate insecticides have become increasingly popular for agricultural, industrial, and home use and represent a significant potential health risk. We have reviewed the history, pathophysiology, clinical presentation, laboratory findings, differential diagnosis, therapy, and complications of toxic exposure to organophosphates. Promp recognition
J, Tafuri, J, Roberts
openaire   +2 more sources

Microbiota and organophosphates

NeuroToxicology, 2019
Organophosphates (OPs) are important toxic compounds commonly used for a variety of purposes in agriculture, industry and household settings. Consumption of these compounds affects several central nervous system functions. Some of the most recognised consequences of organophosphate pesticide exposure in humans include neonatal developmental ...
Pablo Roman   +3 more
openaire   +3 more sources

Organophosphate poisoning

Pharmacology & Therapeutics, 1993
The present review discusses the structure of the anticholinesterase organophosphates (OPs), which are used predominantly as insecticides. OP poisoning can occur in a variety of situations and can be accidental or suicidal. It is common in developing countries.
openaire   +2 more sources

Pharmacology of organophosphates

Journal of Applied Toxicology, 1994
AbstractThe cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral transmitter, and the results of their activation are listed. The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described.
openaire   +2 more sources

Organophosphates, Serine Esterase Inhibition, and Modeling of Organophosphate Toxicity

Toxicological Sciences, 2004
The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be ...
Janice, Chambers, Seth F, Oppenheimer
openaire   +2 more sources

Cardiodepression in Organophosphate Poisonings [PDF]

open access: possible, 1985
During clinical epidemiological investigation of acute human organophosphate intoxication a cardiodepressive form of poisoning was recognised. It had a bad prognosis with a high incidence of lethality. The cardiodepressive form involved mechano- and electrodepression which were manifested in cardiogenic shock and sudden atrioventricular block or both ...
Marosi Gy.   +2 more
openaire   +1 more source

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