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Nephrotoxicity issues of organophosphates
Toxicology, 2018Organophosphates are a large class of chemicals, initially invented in 1850 and since then they have been applied in numerous aspects of science to serve our purposes. Their mechanism of action in living organisms involves the irreversible inhibition of acetylcholinesterase, therefore they interfere with neuromuscular signal transmission.
G. Georgiadis +10 more
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Percutaneous Organophosphate Poisoning
Southern Medical Journal, 1987After cutaneous application of the organophosphate insecticide Diazinon for pubic lice, our patient had symptoms of cholinergic excess, lost consciousness, and had a seizure. Because of the high index of clinical suspicion for potentially lethal organophosphate poisoning, the patient received empiric therapy with pralidoxime and atropine and completely
A, Halle, D D, Sloas
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A Review of Organophosphate Poisoning
Medical Toxicology, 1988Many organophosphate compounds are pesticides widely used for the control of insect vectors. They are not ideal agents because they lack target vector selectivity, and have caused severe toxicity and even death in humans and domestic animals. Their toxicity has been recognised since the 1930s, when they were also developed for use as chemical warfare ...
N A, Minton, V S, Murray
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Organophosphate polyneuropathy in chicks
Biochemical Pharmacology, 1993Young animals are resistant to organophosphate-induced delayed neuropathy (OPIDP), although biochemical changes on Neuropathy Target Esterase (NTE) caused by neuropathic organophosphorus esters (OP) are similar to those observed in the sensitive hen. We report here that the resistance of chicks to single doses of neuropathic OPs is not absolute because
PERAIC M +3 more
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Therapy In Organophosphate Poisoning
Acta Clinica Belgica, 1976SummaryThe therapy of an intoxication by cholinesterase-inhibitors consists of the administration of atropine for symptomatic treatment, of the administration of oximes as a causal therapy and of general supportive measures. The dose of atropine is chosen according to the intensity of the poisoning; the therapeutic use of oximes is briefly discussed.
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The Management of Organophosphate Intoxication
Southern Medical Journal, 1975This review attempts to reiterate the problem of organophosphate intoxication and the pathophysiologic problems created by these compounds. A discussion of management is included. The case reported of a two-year old child serves to illustrate the tremendously high doses of atropine which may be required to block the acetylcholine accumulated at ...
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Endocrine disrupting toxicity of aryl organophosphate esters and mode of action
Critical Reviews in Environmental Science and Technology, 2023Peng Gao, Jianying Hu
exaly