Organoplatinum Compounds as Anion-Tuneable Uphill Hydroxide Transporters. [PDF]
Angew Chem Int Ed Engl, 2022 AbstractActive transport of ions uphill, creating a concentration gradient across a cell membrane, is essential for life. It remains a significant challenge to develop synthetic systems that allow active uphill transport. Here, a transport process fuelled by organometallic compounds is reported that creates a pH gradient.
Chen LJ, Wu X, Gilchrist AM, Gale PA.
europepmc +4 more sources
Design, Synthesis, Characterization, and Antiproliferative Activity of Organoplatinum Compounds Bearing a 1,2,3-Triazole Ring [PDF]
ACS Omega, 2019 The syntheses, characterizations, and biological activities of three organoplatinum compounds, each containing a triazole ring, are discussed. These organometallic compounds demonstrate superior cytotoxicity against osteosarcoma and human breast cancer cells relative to cisplatin, a well-known chemotherapeutic agent used for chemotherapy.
Khushwant Singh +4 more
doaj +2 more sources
Thermal rearrangements of organoplatinum (II) compounds [PDF]
, 1985 Imperial Users ...
Griffiths, D. C., Griffiths, D. C.
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Cellular Physiology and Biochemistry, 2015 Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels in glioma cells is poorly understood.
Mei-Han Huang +2 more
doaj +1 more source
Peripherally-metallated porphyrins: meso-n1-porphyrinyl-platinum(II) complexes of 5,15-diaryl- and 5,10,15-triarylporphyrins [PDF]
, 2002 Attempted metathesis reactions of peripherally-metallated meso-η1-porphyrinylplatinum(II) complexes such as trans-[PtBr(NiDPP)(PPh3)2] (H2DPP = 5,15-diphenylporphyrin) with organolithium reagents fail due to competitive addition at the porphyrin ring ...
Arnold, Dennis +2 more
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Phosphido pincer complexes of platinum: synthesis, structure and reactivity [PDF]
, 2011 A series of platinum(II) complexes supported by the tridentate bis(phosphine)phosphido ligand bis(2-diisopropylphosphinophenyl)phosphide) [iPr–PPP] have been synthesized and characterized (1–4).
Kühl, Olaf +3 more
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Comparing Protonolysis and Transmetalation Reactions: Microcalorimetric Studies of C–AuI Bonds in [AuRL] Complexes [PDF]
, 2018 Producción CientíficaThe protonolysis of C–Au bonds in [AuRL] organometallic complexes has been studied by calorimetry for twelve R groups. The experimental data have been combined with DFT calculations to obtain Bond Dissociation Energy values (BDE).
Casares González, Juan Ángel +2 more
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Role of Axial Ligation in Gating the Reactivity of Dimethylplatinum(III) Diimine Radical Cations [PDF]
, 2021 Electrochemical methods are coupled with chemical oxidant-based analytical strategies to evaluate the oxidative reactivity of the platinum(II) diimine complex (bpy)PtII(CH3)2 (bpy = 2,2'-bipyridine) in coordinating and noncoordinating media.
Dempsey, Jillian L. +7 more
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Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial [PDF]
, 2011 BACKGROUND: The optimum use of cytotoxic drugs for advanced colorectal cancer has not been defined. Our aim was to investigate whether combination treatment is better than the sequential administration of the same drugs in patients with advanced ...
A. Azzedine +19 more
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Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. [PDF]
, 2015 BackgroundDemethylation process is necessary for the expression of various factors involved in chemotherapy cytotoxicity or resistance. Platinum-resistant cells may have reduced expression of the copper/platinum transporter CTR1.
Culotta, Kirk +15 more
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