Results 1 to 10 of about 1,578,947 (161)

Organoplatinum Compounds as Anion-Tuneable Uphill Hydroxide Transporters. [PDF]

Angew Chem Int Ed Engl, 2022
AbstractActive transport of ions uphill, creating a concentration gradient across a cell membrane, is essential for life. It remains a significant challenge to develop synthetic systems that allow active uphill transport. Here, a transport process fuelled by organometallic compounds is reported that creates a pH gradient.
Chen LJ, Wu X, Gilchrist AM, Gale PA.
europepmc   +11 more sources

Design, Synthesis, Characterization, and Antiproliferative Activity of Organoplatinum Compounds Bearing a 1,2,3-Triazole Ring [PDF]

ACS Omega, 2019
The syntheses, characterizations, and biological activities of three organoplatinum compounds, each containing a triazole ring, are discussed. These organometallic compounds demonstrate superior cytotoxicity against osteosarcoma and human breast cancer cells relative to cisplatin, a well-known chemotherapeutic agent used for chemotherapy.
Khushwant Singh, Ankit Gangrade, Achintya Jana, Biman B. Mandal, Neeladri Das   +4 more
doaj   +5 more sources

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca2+-Activated K+ Channels in Human Glioma Cells

Cellular Physiology and Biochemistry, 2015
Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels in glioma cells is poorly understood.
Mei-Han Huang, Yan-Ming Huang, Sheng-Nan Wu   +2 more
doaj   +1 more source

Anticancer Structure–Activity Relationship in Well-Characterized Pt(IV) Compounds: Pt(CH₃)₂I₂{6,6′-dimethyl-2,2′-bipyridine} Cytotoxicity Against Colon and Ovarian Carcinoma Cell Lines

Crystals
Well-defined, small-molecule, platinum-centered coordination compounds are of continued interest in both basic and applied research, particularly in medicinal chemistry and pharmaceuticals (i.e., cisplatin).
Shadrach Stitz, William A. Howard, Kraig A. Wheeler, Natarajan Ganesan, David G. Churchill   +4 more
doaj   +1 more source

Benzylidene insertion reactions in organoplatinum chemistry: mechanism and selectivity. [PDF]

RSC Adv
Moustafa ME, Boyle PD, Puddephatt RJ.
europepmc   +1 more source

An uncommon encounter with tumor lysis syndrome in colorectal cancer. [PDF]

Ger Med Sci
de Matos UMA, Tan WY, Da Silva Santiago MD, Wu Q, Forouhar F, Vankina R, Kapadia P, Forbes V.   +7 more
europepmc   +1 more source

Organoplatinum(II) Type II Immunogenic Cell Death Inducers Target Protein Tyrosine Phosphatase 1B to Drive Immunogenicity. [PDF]

J Am Chem Soc
Zou JX, Ivanov-Rostovtsev PA, Arakelyan J, Babak MV, Ang WH.   +4 more
europepmc   +1 more source

Foreword to the focus issue, 'nanoarchitectonics reloaded: method for everything in materials science'. [PDF]

Sci Technol Adv Mater
Ariga K.
europepmc   +1 more source

FOLFOXIRI plus panitumumab for left-sided RAS-wild-type metastatic colorectal cancer. [PDF]

Oncologist
Hochster HS, Blatchford PJ, Stein S, Lacy J, Kasi A, Boland PM, Gold P, Scott AJ, Oberstein P, Cusnir M, Rouse K, Mallalieu K, Saeed A, AGICC Group.   +13 more
europepmc   +1 more source

Bacterial Ghosts as Innovative Transport Vehicles for Platinum-Based Anticancer Drugs. [PDF]

ChemMedChem
Pashkunova-Martic I, Klose MHM, Kudela P, Groza-Weber D, Reipert S, Kowol CR, Heffeter P, Berger W, Keppler BK, Lubitz W.   +9 more
europepmc   +1 more source