Results 71 to 80 of about 557,652 (262)

Quantifying movement of optical structures during radiotherapy treatment for tumors near the orbita

Physics and Imaging in Radiation Oncology
Background and purpose: Movement of optical structures during radiotherapy for tumors near the orbita might affect the amount of radiation given and consequently the risk for side effects. The aim of this study was therefore to quantify motion of optical
Femke Vaassen, David Hofstede, Nikolina Birimac, Inge Compter, Marlies Granzier, Wouter van Elmpt, Catharina M.L. Zegers, Daniëlle B.P. Eekers   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Is the human testis still an organ at risk? [PDF]

BMJ, 1996
Although several lines of circumstantial evidence suggest that we may be seeing adverse changes in male reproductive health, it is the possibility that semen quality may have declined that has attracted most attention. In a meta-analysis Carlsen et al examined data from 61 papers published between 1938 and 1991 on the quality of semen in normal men.1 ...
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Dosimetric Impact of Interfractional Variations for Post-prostatectomy Radiotherapy to the Prostatic Fossa—Relevance for the Frequency of Position Verification Imaging and Treatment Adaptation

Frontiers in Oncology, 2019
Background and purpose: To analyze divergences between the planned and applied treatment doses for post-prostatectomy radiotherapy to the prostatic fossa on a voxel-by-voxel basis based on interfractional anatomic variations and imaging frequency ...
Mona Splinter, Mona Splinter, Mona Splinter, Tilman Bostel, Tilman Bostel, Tilman Bostel, Ilias Sachpazidis, Ilias Sachpazidis, Tobias Fechter, Tobias Fechter, Constantinos Zamboglou, Constantinos Zamboglou, Oliver Jäkel, Oliver Jäkel, Peter E. Huber, Peter E. Huber, Peter E. Huber, Jürgen Debus, Jürgen Debus, Jürgen Debus, Dimos Baltas, Dimos Baltas, Nils H. Nicolay, Nils H. Nicolay, Nils H. Nicolay, Nils H. Nicolay   +25 more
doaj   +1 more source

Quality assurance of organs-at-risk delineation in radiotherapy

CoRR
The delineation of tumor target and organs-at-risk is critical in the radiotherapy treatment planning. Automatic segmentation can be used to reduce the physician workload and improve the consistency. However, the quality assurance of the automatic segmentation is still an unmet need in clinical practice.
Yihao Zhao, Cuiyun Yuan, Ying Liang, Yang Li, Chunxia Li, Man Zhao, Jun Hu 0020, Wei Liu 0022, Chenbin Liu   +8 more
openaire   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Dosimetric Impact of Interfractional Variations in Prostate Cancer Radiotherapy—Implications for Imaging Frequency and Treatment Adaptation

Frontiers in Oncology, 2019
Background and purpose: To analyze deviations of the applied from the planned doses on a voxel-by-voxel basis for definitive prostate cancer radiotherapy depending on anatomic variations and imaging frequency.Materials and methods: Daily in-room CT ...
Tilman Bostel, Tilman Bostel, Tilman Bostel, Ilias Sachpazidis, Ilias Sachpazidis, Mona Splinter, Mona Splinter, Nina Bougatf, Nina Bougatf, Nina Bougatf, Tobias Fechter, Tobias Fechter, Constantinos Zamboglou, Constantinos Zamboglou, Oliver Jäkel, Oliver Jäkel, Peter E. Huber, Peter E. Huber, Peter E. Huber, Dimos Baltas, Dimos Baltas, Jürgen Debus, Jürgen Debus, Jürgen Debus, Nils H. Nicolay, Nils H. Nicolay, Nils H. Nicolay   +26 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source