Results 81 to 90 of about 41,541,189 (252)

Dosimetric Impact of Interfractional Variations in Prostate Cancer Radiotherapy—Implications for Imaging Frequency and Treatment Adaptation

Frontiers in Oncology, 2019
Background and purpose: To analyze deviations of the applied from the planned doses on a voxel-by-voxel basis for definitive prostate cancer radiotherapy depending on anatomic variations and imaging frequency.Materials and methods: Daily in-room CT ...
Tilman Bostel, Tilman Bostel, Tilman Bostel, Ilias Sachpazidis, Ilias Sachpazidis, Mona Splinter, Mona Splinter, Nina Bougatf, Nina Bougatf, Nina Bougatf, Tobias Fechter, Tobias Fechter, Constantinos Zamboglou, Constantinos Zamboglou, Oliver Jäkel, Oliver Jäkel, Peter E. Huber, Peter E. Huber, Peter E. Huber, Dimos Baltas, Dimos Baltas, Jürgen Debus, Jürgen Debus, Jürgen Debus, Nils H. Nicolay, Nils H. Nicolay, Nils H. Nicolay   +26 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Analyzing the Relationship between Dose and Geometric Agreement Metrics for Auto-Contouring in Head and Neck Normal Tissues

Diagnostics
This study aimed to determine the relationship between geometric and dosimetric agreement metrics in head and neck (H&N) cancer radiotherapy plans. A total 287 plans were retrospectively analyzed, comparing auto-contoured and clinically used contours ...
Barbara Marquez, Zachary T. Wooten, Ramon M. Salazar, Christine B. Peterson, David T. Fuentes, T. J. Whitaker, Anuja Jhingran, Julianne Pollard-Larkin, Surendra Prajapati, Beth Beadle, Carlos E. Cardenas, Tucker J. Netherton, Laurence E. Court   +12 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Daily dose to organs at risk predicts acute toxicity in pancreatic stereotactic radiotherapy

, 2020
Daily dose to organs at risk predicts acute toxicity in pancreatic stereotactic ...
Alba Magallon-Baro (8614395), Mustafa Suker (4556905), Mischa Hoogeman (8614401), Casper Van Eijck (8614398), Mauro Loi (8614392), Joost J. Nuyttens (6406163)   +5 more
core   +1 more source

Dosimetric Comparison between Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy in Head and Neck Cancer

Arcades of Medicine
Background: Head and neck cancer remains a major global oncological burden and often requires highly conformal radiotherapy because target volumes are complex and lie close to critical organs.
Abdel-Rahman Tawfeek, Tarek Hashem, Khaled Elshahat, Hany Atallah   +3 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Comparison of dose parameters to the organs at risk.

, 2013
Organs at risk: a) Esophagus, b) heart, c) major airway, d) major vessels, e) spinal cord, f) and g) mean lung dose (MLD) and V20 for the total lung, after normalized to the absolute dose constraints between helical tomotherapy (Tomo), 2-arc, and 8-arc ...
Guishan Fu (400071), Gerry Hobbs (400072), Jinrong Dai (400073), Jing Jin (18601), Nam P. Nguyen (310988), Alexander Chi (310989), Si Young Jang (325193), Pan Ma (400070), Ritsuko Komaki (325195), James S. Welsh (325192)   +9 more
core   +1 more source

A pilot study on interobserver variability in organ-at-risk contours in magnetic resonance imaging-guided online adaptive radiotherapy for pancreatic cancer

Frontiers in Oncology
PurposeDifferences in the contours created during magnetic resonance imaging-guided online adaptive radiotherapy (MRgOART) affect dose distribution. This study evaluated the interobserver error in delineating the organs at risk (OARs) in patients with ...
Marie Kurokawa, Masato Tsuneda, Kota Abe, Yohei Ikeda, Aki Kanazawa, Makoto Saito, Asuka Kodate, Rintaro Harada, Hajime Yokota, Miho Watanabe, Takashi Uno   +10 more
doaj   +1 more source