Results 61 to 70 of about 41,541,189 (252)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

SegTHOR: Segmentation of Thoracic Organs at Risk in CT images

, 2020
International audienceIn the era of open science, public datasets, along with common experimental protocol, help in the process of designing and validating data science algorithms; they also contribute to ease reproductibility and fair comparison between
Kuan, Su, Petitjean, Caroline, Su Kuan, Bernard Dubray, Lambert, Zoe, Dubray, Bernard, Caroline Petitjean, Zoe Lambert   +7 more
core   +1 more source

Association of postoperative haemoglobin with adverse outcomes in patients undergoing cardiac surgery: a retrospective single centre cohort study

BJA Open
Background: Preoperative anaemia is an important risk factor for adverse outcomes in cardiac surgery, however data on postoperative anaemia is sparse.
Jamal Alkadri, Maggie Chen, Keyvan Karkouti, Samantha Morais, Refik Saskin, Alexa Grudzinski, Maral Ouzounian, Jeannie Callum, Yulia Lin, Stuart A. McCluskey, Daniel I. McIsaac, Justyna Bartoszko   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A modality-adaptive method for segmenting brain tumors and organs-at-risk in radiation therapy planning [PDF]

, 2019
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas.
Lundemann, MJ, Van Leemput, K, Thust, S, Mancini, L, Papadaki, A, Agn, M, Puonti, O, Munck Af Rosenschöld, P, Ashburner, J, Law, I   +9 more
core   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Atlas for the delineation for organs-at-risk in NSCLC

, 2017
Please find two atlasses below for the contouring of critical organs-at-risk: one for Heart PRV, Esophagus, Spinal Cord and another for Brachial ...
Inga Grills, Jan-Jakob Sonke, Matthias Guckenberger, Andrew Hope, José Belderbos, Heike Peulen, Marcel van Herk   +6 more
core   +1 more source

Tolerated dose of organs at risk in radiotherapy of head and neck area [32].

, 2022
Tolerated dose of organs at risk in radiotherapy of head and neck area [32].
Amir Hossein Karimi (13175885), Iraj Abedi (13175873), Soheil Elmtalab (13175870), Ghazale Geraily (13175882), Mohammad Hossein Choopan Dastjerdi (13175879), Zahra Alirezaei (13175876)   +5 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source