Results 111 to 120 of about 574,013 (307)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Preliminary evaluation of using machine learning to prioritise cancer patients for proton radiotherapy by predicting dose to organs at risk [PDF]

, 2019
The investment in proton radiation therapy raises the question of how cancer patients should be prioritised for this treatment method. A large advantage to proton therapy is that one can minimise the radiation received by organs at risk. Machine learning
Claesson, Linda Josephine
core  

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. [PDF]

, 2014
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene ...
Olson, J.E., Spurdle, A.B., Schrauwen, S., Doerk, T., Hall, P, CHIBCHA Consortium, Werner, HM, Webb, PM, Tzortzatos, G., Long, J., Liu, J., Hein, A, Amant, F., Tomlinson, I., Ruebner, M, Attia, J., McEvoy, M., Shu, X.-O., Rojas-Martinez, A, Martin, N.G., Zheng, W., Proietto, T, Dieffenbach, AK, Rudolph, A, Meindl, A., Swerdlow, A.J., Dunning, A.M., Santos, E., Dowdy, SC, Ferguson, K, Batra, J., Tyrer, J.P., De Polanco, MM, Lambrechts, D., Pollock, P, Salvesen, H.B., Hopper, JL, Coenegrachts, L., Fasching, P.A., Runnebaum, I., Michailidou, K., Ekici, A.B., Wang, Q, Batra, J, Johnson, N., Henders, AK, Canc, ANE, Marme, F., Ferguson, K., Montgomery, G.W., Ahmed, S, Spurdle, AB, Otton, G., Dunning, AM, Czene, K, Burwinkel, B, Easton, DF, Liu, J, Sans, M., Otton, G, Healey, C.S., Teoman, A., Ruebner, M., Borresen-Dale, A.-L., Bolla, MK, French, JD, Werner, H.M.J., Carracedo, A., RENDOCAS, Ahmed, S., Painter, JN, Trovik, J., Cheng, T, Fridley, BL, Shu, X-O., Orr, N., Borresen-Dale, A-L., Marme, F, Painter, J.N., Winterhoff, B, Teoman, A, O'Mara, T.A., Australian Ovarian Cancer Study (AOCS), Lindblom, A., Consortium, CHIBCHA, Mints, M., Scott, R.J., Southey, M.C., Canc, N.S.E., Martin, NG, Gorman, M., Bolla, M.K., Shu, XO, Johnson, N, Chang-Claude, J, Amant, F, Bruinsma, F, Cunningham, JM, Olson, JE, Henders, A.K., Moisse, M, Castellvi-Bel, S., Pollock, P., Li, J, Hopper, J.L., Dennis, J, Cox, A, Ashton, K., Hall, P., Hillemanns, P., Weber, R.P., Depreeuw, J, Magdalena Echeverry De Polanco, M., Dork, T., Ekici, AB, Dürst, M, Brauch, H, Pharoah, P.D.P., Moisse, M., Network, GENICA, Dennis, J., Peto, J, Trovik, J, McEvoy, M, Edwards, SL, Lose, F.A., Xiang, Y-B., Goode, E.L., Lambrechts, D, Howarth, K, Teixeira, M.R., Kaufmann, S., Renner, SP, De Polanco, MME, Weber, RP, O'Mara, TA, Mints, M, Cunningham, J.M., AOCS, Jones, A., Gorman, M, Santos, E, Beckmann, M.W., Tomlinson, I, Fridley, B.L., Castellvi-Bel, S, Giles, GG, Dowdy, S.C., Schrauwen, S, Montgomery, GW, Martin, L., Xiang, Y.-B., Teixeira, MR, Tham, E, Wang, Q., Thompson, DJ, Proietto, T., Coenegrachts, L, GENICA Network, Cheng, T., Lindblom, A, Nyholt, D.R., Brenner, H., Attia, J, Li, J., Carvajal-Carmona, L., Long, J, Tzortzatos, G, Swerdlow, AJ, Pollock, P.M., Couch, FJ, Fasching, PA, Southey, MC, Meindl, A, Hillman, KM, Brauch, H., Moya, L., Burwinkel, B., Bruinsma, F., Howarth, K., French, J.D., Hodgson, S., Orr, N, Lose, FA, Scott, RJ, Børresen-Dale, AL, Czene, K., Pharoah, PD, Renner, S.P., Holliday, E., Hodgson, S, National Study of Endometrial Cancer Genetics Group (NSECG), Beckmann, MW, Kaufmann, S, Chen, Z., Martin, L, Walpole, C., Tyrer, JP, Shah, M., Healey, CS, Walpole, C.M., Brenner, H, Winterhoff, B., Hillman, K.M., Carvajal-Carmona, L, Kristensen, VN, Durst, M., Sans, M, Ashton, K, Duerst, M., Rojas-Martinez, A., Moya, L, Giles, G.G., Walpole, C, Jones, A, Xiang, YB, Cox, A., Tham, E., Runnebaum, I, Salvesen, HB, Werner, HMJ, Holliday, E, Peto, J., Couch, F.J., Carracedo, A, Hillemanns, P, Chen, Z, Depreeuw, J., Webb, P.M., Rudolph, A., Michailidou, K, Njolstad, T.S., Chang-Claude, J., Easton, D.F., Australian National Endometrial Cancer Study Group (ANECS), Thompson, D.J., Shah, M, Zheng, W, Edwards, S.L., Dieffenbach, A.K., Njolstad, TS, De Polanco, M.M.E., Dörk, T, Kristensen, V.N., Nyholt, DR, Goode, EL, Hein, A.   +246 more
core   +1 more source

A deep learning segmentation method to assess dose to organs at risk during breast radiotherapy

, 2023
Background and purpose: Contouring of organs at risk is important for studying health effects following breast radiotherapy. However, manual contouring is time-consuming and subject to variability. The purpose of this study was to develop a deep learning-
Monjoy Saha, Choonsik Lee, Choonik Lee, Jae Won Jung, Sung-Woo Lee, Matthew M. Mille   +5 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Toxicity risk of non-target organs at risk receiving low-dose radiation: case report

, 2010
[[abstract]]The spine is the most common site for bone metastases. Radiation therapy is a common treatment for palliation of pain and for prevention or treatment of spinal cord compression. Helical tomotherapy (HT), a new image-guided intensity modulated
Pei-Wei Shueng;Shih-Chiang Lin;Hou-Tai Chang;Ngot-Swan Chong;Yu-Jen Chen;Li-Ying Wang;Yen-Ping Hsieh;Chen-Hsi Hsieh
core  

Dosimetric parameters comparison for the organs at risk: Total lung, heart, spinal cord, and spinal cord PRV.

, 2018
Dosimetric parameters comparison for the organs at risk: Total lung, heart, spinal cord, and spinal cord PRV.
Lirong Fu (674897), Qin Lin (406035), Youqun Lai (674895), Liwan Shi (674896), Shanyu Chen (703655)   +4 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source