Results 91 to 100 of about 574,013 (307)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Risk reduction of radiation-induced aspiration by sparing specific aspiration-related-organs at risk; an in silico feasibility study [PDF]

Purpose: To assess the feasibility and benefit of NTCP optimized aspiration-prevention treatment planning by sparing specific aspiration related organs at risk, and to assess the impact of baseline complaints on the planning results.
van der Schaaf, Arjen; id_orcid, Gawryszuk, Agata; id_orcid, van der Laan, Hans Paul, Langendijk, Johannes A.; id_orcid   +3 more
core   +1 more source

Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT

, 2022
This study evaluated dose differences in normal organs at risk, such as the lungs, heart, left anterior descending artery (LAD), right coronary artery, left ventricle, and right breast under personalized breast holder (PERSBRA), when using intensity ...
Jeng-Fong Chiou, Chen, Chun-You, Chiu-Ping Chen, Yi-Ju Chen, Kuo, Chia-Chun, Chung, Meng-Yun, Jeng-You Wu, Chia-Chun Kuo, Chun-You Chen, Hsu, Shih-Ming, Tseng, Kuo-Hsiung, Wu, Jeng-You, Chiou, Jeng-Fong, Chen, Chiu-Ping, Chen, Tung-Ho, Shih-Ming Hsu, Chen, Yi-Ju, Long-Sheng Lu, Lu, Long-Sheng, Kuo-Hsiung Tseng, Meng-Yun Chung, Tung-Ho Chen   +21 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain [PDF]

, 2018
  EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain In collaboration with the European Particle Therapy Network, a consensus table of tolerance doses for Organs at Risk in the brain was created ...
Ans Swinnen, Daniëlle BP Eekers, Erik Roelofs, Petra De Witt Nyström, Frederik WR Wesseling, Esther GC Troost, Maarten Lambrecht   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The potential cancer risk on body organs as abdomen CT-scan exposure result

, 2021
Research has been carried out on the Potential Risk of Cancer in Body Organs Due to Abdomen CT Scan Radiation. The use of a CT-Scan tool that emits radiation has the potential to have quite a serious impact.
Manuaba, Ida Bagus Putra, Suryatika, Ida Bagus Made, Yasa, I Wayan Putu Sutirta, Sutapa, Gusti Ngurah, Poniman, S.   +4 more
core   +1 more source

Quantifying movement of optical structures during radiotherapy treatment for tumors near the orbita

Physics and Imaging in Radiation Oncology
Background and purpose: Movement of optical structures during radiotherapy for tumors near the orbita might affect the amount of radiation given and consequently the risk for side effects. The aim of this study was therefore to quantify motion of optical
Femke Vaassen, David Hofstede, Nikolina Birimac, Inge Compter, Marlies Granzier, Wouter van Elmpt, Catharina M.L. Zegers, Daniëlle B.P. Eekers   +7 more
doaj   +1 more source

Risk Categories and Risk Management Processes in Nonprofit Organizations [PDF]

Foundations of Management, 2016
Abstract The article addresses risk management in nonprofit organizations. This topical issue appears not to have been adequately studied by researchers to date. There are several questions the author of this paper attempts to answer: What are the risk categories faced by nonprofit organizations in their daily operations?
openaire   +3 more sources