Results 91 to 100 of about 40,966,695 (254)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A pilot study on interobserver variability in organ-at-risk contours in magnetic resonance imaging-guided online adaptive radiotherapy for pancreatic cancer

Frontiers in Oncology
PurposeDifferences in the contours created during magnetic resonance imaging-guided online adaptive radiotherapy (MRgOART) affect dose distribution. This study evaluated the interobserver error in delineating the organs at risk (OARs) in patients with ...
Marie Kurokawa, Masato Tsuneda, Kota Abe, Yohei Ikeda, Aki Kanazawa, Makoto Saito, Asuka Kodate, Rintaro Harada, Hajime Yokota, Miho Watanabe, Takashi Uno   +10 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Defining and sparing sexual function-related organs at risk for rectal cancer radiotherapy [PDF]

Background and purpose: Sexual dysfunction is a common consequence of pelvic radiotherapy, influenced by psychological, physical, social, and relational factors.
Susan B N Biancardo, Poulsen, Laurids; id_orcid, Johanne H Steffensen, Rønde, Heidi S., Biancardo, Susan B N, Lutz, Christina M, Stine E Petersen, Szpejewska, Joanna, Hvid, Christian A., Pedersen, Bodil G, Camilla J S Kronborg, Laura V Diness, Fokdal, Lars U, Serup-Hansen, Eva, Poulsen, Laurids Ø, Nissen, Henrik D., Jimmi Søndergaard, Lise K Schou, Schou, Lise K., Jakobsen, Kirsten L., Hvid, Christian A, Steffensen, Johanne H, Havelund, Birgitte, Lutz, Christina M., Rana Bahij, Bodil G Pedersen, Schou, Lise K, Birthe T Oggesen, Nyvang, Lars, Oggesen, Birthe T., Petersen, Stine E, Diness, Laura V., Kathrin Kirchheiner, Szpejewska, Joanna E., Kirchheiner, Kathrin, Lars Nyvang, Kronborg, Camilla J.S., Bahij, Rana, Jakobsen, Kirsten L, Lars U Fokdal, Arp, Dennis T, Søndergaard, Jimmi, Christian A Hvid, Birgitte Havelund, Poulsen, Laurids, Joanna Szpejewska, Rønde, Heidi S, Biancardo, Susan B.N., Heidi S Rønde, Engstrøm, Kenni H, Engstrøm, Kenni H., Eva Serup-Hansen, Henrik D Nissen, Steffensen, Johanne H., Laurids Ø Poulsen, Kronborg, Camilla J S, Dennis T Arp, Kenni H Engstrøm, Christina M Lutz, Pedersen, Bodil G., Kirsten L Jakobsen, Pedersen, Stine E., Nissen, Henrik D, Oggesen, Birthe T, Fokdal, Lars U., Arp, Dennis T., Diness, Laura V   +66 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Daily dose to organs at risk predicts acute toxicity in pancreatic stereotactic radiotherapy

, 2020
Daily dose to organs at risk predicts acute toxicity in pancreatic stereotactic ...
Alba Magallon-Baro (8614395), Mustafa Suker (4556905), Mischa Hoogeman (8614401), Casper Van Eijck (8614398), Mauro Loi (8614392), Joost J. Nuyttens (6406163)   +5 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Risk factors for pelvic organ prolapse

International Journal of Gynecology & Obstetrics, 2007
AbstractObjectives: To evaluate the risk factors for pelvic organ prolapse (POP) and to determine the relationship between these risk factors and stage or other components of POP. Methods: 244 patients with primary POP and 314 women without POP were included.
C M, Kim, M J, Jeon, D J, Chung, S K, Kim, J W, Kim, S W, Bai   +5 more
openaire   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source