Results 71 to 80 of about 40,966,695 (254)

Pelvic U-Net: multi-label semantic segmentation of pelvic organs at risk for radiation therapy anal cancer patients using a deeply supervised shuffle attention convolutional neural network

Radiation Oncology, 2022
Background Delineation of organs at risk (OAR) for anal cancer radiation therapy treatment planning is a manual and time-consuming process. Deep learning-based methods can accelerate and partially automate this task.
Michael Lempart, Martin P. Nilsson, Jonas Scherman, Christian Jamtheim Gustafsson, Mikael Nilsson, Sara Alkner, Jens Engleson, Gabriel Adrian, Per Munck af Rosenschöld, Lars E. Olsson   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multi-organ Mapping of Cancer Risk [PDF]

Cell, 2016
Cancers are distributed unevenly across the body, but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used Cre-recombination of conditional lineage tracing, oncogene, and tumor suppressor alleles to define populations of stem and non-stem cells in mouse organs and test their
Zhu, Liqin, Finkelstein, David, Gao, Culian, Shi, Lei, Wang, Yongdong, López-Terrada, Dolores, Wang, Kasper, Utley, Sarah, Pounds, Stanley, Neale, Geoffrey, Ellison, David, Onar-Thomas, Arzu, Gilbertson, Richard James   +12 more
openaire   +2 more sources

A modality-adaptive method for segmenting brain tumors and organs-at-risk in radiation therapy planning [PDF]

, 2019
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas.
Lundemann, MJ, Van Leemput, K, Thust, S, Mancini, L, Papadaki, A, Agn, M, Puonti, O, Munck Af Rosenschöld, P, Ashburner, J, Law, I   +9 more
core   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Clinical advances and challenges in dose constraints for organs at risk in proton therapy: A systematic review of the last decade's literature

Precision Radiation Oncology
Proton beam therapy has demonstrated significant clinical efficacy across multiple malignancies, primarily attributed to its distinct physical dose deposition characteristics.
Jinghao Duan, Cheng Tao, Shizhang Wu, Chengqiang Li, Jinhu Chen, Tianyuan Dai, Yunyi Fan, Tong Bai, Xiangjuan Meng, Tian Kong, Jian Zhu   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Atlas for the delineation for organs-at-risk in NSCLC

, 2017
Please find two atlasses below for the contouring of critical organs-at-risk: one for Heart PRV, Esophagus, Spinal Cord and another for Brachial ...
Inga Grills, Jan-Jakob Sonke, Matthias Guckenberger, Andrew Hope, José Belderbos, Heike Peulen, Marcel van Herk   +6 more
core   +1 more source

Tolerated dose of organs at risk in radiotherapy of head and neck area [32].

, 2022
Tolerated dose of organs at risk in radiotherapy of head and neck area [32].
Amir Hossein Karimi (13175885), Iraj Abedi (13175873), Soheil Elmtalab (13175870), Ghazale Geraily (13175882), Mohammad Hossein Choopan Dastjerdi (13175879), Zahra Alirezaei (13175876)   +5 more
core   +1 more source

Deep learning-based delineation of whole-body organs at risk empowering adaptive radiotherapy

BMC Medical Informatics and Decision Making
Background Accurate delineation of organs at risk (OARs) is crucial for precision radiotherapy. Most previous autosegmentation models were only constructed for single anatomical region without evaluation of dosimetric impact.
Zi-Hang Chen, Song-Feng Li, Ling-Xin Xu, Meng-Qiu Tian, Feng Li, Yu-Xian Yang, Chen-Fei Wu, Guan-Qun Zhou, Li Lin, Yao Lu, Ying Sun   +10 more
doaj   +1 more source