Results 81 to 90 of about 574,013 (307)

Development of explanatory movies for the delineation of new organs at risk in neuro-oncology

, 2022
Ten new organs at risk (OARs) were recently introduced in the updated European Particle Therapy Network neurological contouring atlas. Despite the use of the illustrated atlas and descriptive text, interindividual contouring variations may persist.
Troost, Esther G C, Lieke In't Ven, Wouter van Elmpt, Postma, Alida; id_orcid, Compter, Inge, Beurskens, Hilde, David Hofstede, Danielle B.P. Eekers, Di Perri, Dario, Dario Di Perri, Hofstede, David, Eekers, Danielle B.P., Postma, Alida, van Elmpt, Wouter, Verheesen, Lindsey, Hilde Beurskens, Lindsey Verheesen, Troost, Esther G.C., Catharina M.L. Zegers, Inge Compter, Eekers, Danielle B P, Zegers, Catharina M L, Hoebers, Frank, Alida Postma, Frank Hoebers, Zegers, Catharina M.L., Esther G.C. Troost, In't Ven, Lieke   +27 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Percentage volumes receiving at least X% of prescription dose (V_X%) of organs at risk.

, 2018
Percentage volumes receiving at least X% of prescription dose (VX%) of organs at risk.
Kyeong-Hyeon Kim (5954705), Tae Suk Suh (4002299), In-Ah Kim (5954711), Changhoon Song (728439), Jae-Sung Kim (605888), Sang-Won Kang (2372773), Seong-Hee Kang (5954708), Keun-Yong Eom (728442), Jin-Beom Chung (4870483)   +8 more
core   +1 more source

The hierarchy of risks for medical organizations

Problems of Social Hygiene, Public Health and History of Medicine
The efficient functioning of medical organizations is closely related to various external and internal factors. To minimize negative impact of these factors it is necessary to implement risk management concept. The purpose of the study is to rank risks influencing functioning of medical organizations. The A. V. Zavrazhsky typology of risks was applied.
I D, Mirieva, G Y, Sazanova, M V, Erugina, E B, Knyazev, A Y, Gadyatsky, A D, Ponomarev, E A, Vartanov   +6 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pelvic U-Net: multi-label semantic segmentation of pelvic organs at risk for radiation therapy anal cancer patients using a deeply supervised shuffle attention convolutional neural network

Radiation Oncology, 2022
Background Delineation of organs at risk (OAR) for anal cancer radiation therapy treatment planning is a manual and time-consuming process. Deep learning-based methods can accelerate and partially automate this task.
Michael Lempart, Martin P. Nilsson, Jonas Scherman, Christian Jamtheim Gustafsson, Mikael Nilsson, Sara Alkner, Jens Engleson, Gabriel Adrian, Per Munck af Rosenschöld, Lars E. Olsson   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Association of postoperative haemoglobin with adverse outcomes in patients undergoing cardiac surgery: a retrospective single centre cohort study

BJA Open
Background: Preoperative anaemia is an important risk factor for adverse outcomes in cardiac surgery, however data on postoperative anaemia is sparse.
Jamal Alkadri, Maggie Chen, Keyvan Karkouti, Samantha Morais, Refik Saskin, Alexa Grudzinski, Maral Ouzounian, Jeannie Callum, Yulia Lin, Stuart A. McCluskey, Daniel I. McIsaac, Justyna Bartoszko   +11 more
doaj   +1 more source

Multi-organ Mapping of Cancer Risk [PDF]

Cell, 2016
Cancers are distributed unevenly across the body, but the importance of cell intrinsic factors such as stem cell function in determining organ cancer risk is unknown. Therefore, we used Cre-recombination of conditional lineage tracing, oncogene, and tumor suppressor alleles to define populations of stem and non-stem cells in mouse organs and test their
Zhu, Liqin, Finkelstein, David, Gao, Culian, Shi, Lei, Wang, Yongdong, López-Terrada, Dolores, Wang, Kasper, Utley, Sarah, Pounds, Stanley, Neale, Geoffrey, Ellison, David, Onar-Thomas, Arzu, Gilbertson, Richard James   +12 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source