Results 81 to 90 of about 40,966,695 (254)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
20210727_RAG_PRA_Health risk after flooding
, 2021 RAG PRA Health risk after ...
Risk Assessment Group
core
Quantifying movement of optical structures during radiotherapy treatment for tumors near the orbita
Physics and Imaging in Radiation OncologyBackground and purpose: Movement of optical structures during radiotherapy for tumors near the orbita might affect the amount of radiation given and consequently the risk for side effects. The aim of this study was therefore to quantify motion of optical
Femke Vaassen +7 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Risk Categories and Risk Management Processes in Nonprofit Organizations [PDF]
Foundations of Management, 2016 Abstract The article addresses risk management in nonprofit organizations. This topical issue appears not to have been adequately studied by researchers to date. There are several questions the author of this paper attempts to answer: What are the risk categories faced by nonprofit organizations in their daily operations?
openaire +3 more sources
Rogue traders versus value-at-risk and expected shortfall
, 2018 We show that, in a Black and Scholes market, value at risk and ex- pected shortfall are irrelevant in limiting traders excessive tail-risk seeking behaviour as modelled via Kahneman and Tversky’s S-shaped utility. To have effective constraints one can
Brigo, D, Armstrong, John
core
Organs-on-Chips, Microengineered in vitro Models
, 2016 This is the 15' presentation I gave for the 'Connecting U' Symposium 'Engineering Tissues and Organs' at UMC Utrecht on October 24, 2016.
Andries van der Meer (503130)
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Radiation Oncology, 2019 Background We evaluated the optimal radiotherapy (RT) plan for synchronous bilateral breast cancer (SBBC), especially treatment plans including the regional lymph node (LN) area.
Yeona Cho +5 more
doaj +1 more source