Results 101 to 110 of about 356,257 (302)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Is Kazan an oriental city? (Based on the guidebook of 1873)
Ученые записки Казанского университета: Серия Гуманитарные науки, 2018 The guidebook is one of the most genre-defined forms of historical and educational work. Using the example of the text of the “Index of Kazan Historical Sites” by Professor S.M. Shpilevskii, the potential and importance of the guidebook for the formation
E.M. Dusaeva, N.I. Khanbekova
doaj
Mariage tardif et célibat au Moyen-Orient : quels enjeux
, 2008 Arab and Middle Eastern countries have experienced sharp changes in their patterns of nuptiality, a marked decline of age at first marriage since the 1980's, possibly leading to the emergence of significant levels of permanent celibacy, especially among ...
de Bel-Air, Françoise
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
De l'Euphrate au Rhin : aspects de l'hellénisation et de la romanisation du Proche-Orient /
, 1995 "Recueil publié à l'occasion du cinquantenaire de l'Institut français d'archéologie du Proche-Orient et du soixante-quinzième anniversaire de sa revue "Syria", où sont initialement parus vingt-cinq des textes republiés ici."--Dust jacket.Includes ...
Institut français d'archéologie du Proche-orient +1 more
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
, 1936 Sport und Leibesübungen im arabischen Orient / Der Orient falsch gesehen! / Die Aufhebung des Mandats in Syrien / Der Islam eine Gefahr für Europa?
Mohamed Jahia Haschmi
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source