Results 31 to 40 of about 889,181 (180)
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
BMJ OpenIntroduction Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders (NDDs) and is frequently associated with psychiatric and somatic comorbidities.
Alexandra Cordina +4 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Orientable and Negative Orientable Sequences
Discrete Applied MathematicsAnalogously to de Bruijn sequences, orientable sequences have application in automatic position-location applications and, until recently, studies of these sequences focused on the binary case. In recent work by Alhakim et al., a range of methods of construction were described for orientable sequences over arbitrary finite alphabets; some of these ...
Chris J. Mitchell, Peter R. Wild
openaire +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
The Journal for Transdisciplinary Research in Southern Africa, 2021 Life Orientation (LO) as a compulsory subject in the South African school curriculum (Grades 7–12) aims to develop the learner’s self-in-society. This implies a holistic approach that includes the personal, social and physical development of the learner.
Janet Jarvis, Sarina de Jager
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Revista de la Facultad de Medicina, 2023 Introduction: During the COVID-19 pandemic, there was a notable increase in the use of telemedicine as an alternative to provide healthcare services.
Álvaro Daniel Carrizo +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Critical insights for intensivists on Guillain-Barré syndrome
Annals of Intensive CareGuillain-Barré Syndrome (GBS) is a leading cause of acute flaccid tetraplegia worldwide, with an incidence of 1–2 cases per 100,000 people per year.
Nicolas Weiss +4 more
doaj +1 more source