Results 41 to 50 of about 2,833,186 (356)

Patients assessed using teleconsultation due to high blood pressure during the COVID-19 pandemic in Tucumán (Argentina)

open access: yesRevista de la Facultad de Medicina, 2023
Introduction: During the COVID-19 pandemic, there was a notable increase in the use of telemedicine as an alternative to provide healthcare services.
Álvaro Daniel Carrizo   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

[USF] Get Involved with USF Bound, Move-In, and Orientation

open access: yes, 2020
Campus-wide email from the USF Orientation Team providing information regarding key transition events for incoming students and their family ...
Reid, Annie; Campus-wide   +1 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Weaning from mechanical ventilation in myasthenic crisis according to WEAN safe: most patients experience intermediate or prolonged weaning with no differences between early and late-onset compared to very-late onset myasthenia Gravis

open access: yesAnnals of Intensive Care
Background: Myasthenic crisis often requires prolonged mechanical ventilation and complex weaning, yet data remain scarce. The objective of this study was to describe the weaning characteristics in patients with myasthenic crisis using the WEAN Safe ...
Clémence Marois   +10 more
doaj   +1 more source

Completing orientations of partially oriented graphs [PDF]

open access: yesJournal of Graph Theory, 2017
AbstractWe initiate a general study of what we call orientation completion problems. For a fixed class of oriented graphs, the orientation completion problem asks whether a given partially oriented graph P can be completed to an oriented graph in by orienting the (nonoriented) edges in P.
Jørgen Bang-Jensen   +2 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Market Orientation and Organizational Performance: Is Innovation a Missing Link?

open access: yes, 1998
In recent years, a market-oriented corporate culture increasingly has been considered a key element of superior corporate performance. Although organizational innovativeness is believed to be a potential mediator of this market orientation–corporate ...
Jin K. Han, Namwoon Kim, R. Srivastava
semanticscholar   +1 more source

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

open access: yesJournal of Neuroscience, 1982
The development of stimulus selectivity in the primary sensory cortex of higher vertebrates is considered in a general mathematical framework. A synaptic evolution scheme of a new kind is proposed in which incoming patterns rather than converging ...
E. Bienenstock, L. Cooper, P. Munro
semanticscholar   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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