Results 31 to 40 of about 1,865,844 (300)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Halt in Zeit-Spiel-Räumen der menschlichen Orientierung. Zum Umgang mit der Zeit im Nihilismus. Ein Impuls [PDF]

Phainomena
Hold in the Leeway of Time and Space in Human Orientation. On Dealing with Time in Nihilism. An Impulse - Today, we no longer live in a world of final, fixed, absolute certainties, as traditional metaphysics once claimed.
Werner Stegmaier
doaj   +1 more source

Orientation

Curationis, 1985
Oriëntasie van ’n nuwe werknemer is noodsaaklik om angs te verlig en om horn/ haar van die inligting wat nodig is vir bevredigende werksverrigting te voorsien. Orientasieprogramme moet aangepas word by die spesifieke behoeftes van elke nuwe werknemer. Daar kan onderskei word tussen makro- en mikro-oriëntasie.
openaire   +4 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Management of patients with autism spectrum disorder in psychiatric emergency: a single-centre retrospective study

BMJ Open
Introduction Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders (NDDs) and is frequently associated with psychiatric and somatic comorbidities.
Alexandra Cordina, Louise Todorov, Michael Guetta, Alexandra Pham-Scottez, Marine Ambar Akkaoui   +4 more
doaj   +1 more source

Editorial comment

The Journal for Transdisciplinary Research in Southern Africa, 2021
no abstract available.
Janet Jarvis, Sarina de Jager
doaj   +1 more source

On the oriented chromatic index of oriented graphs [PDF]

Journal of Graph Theory, 2007
AbstractA homomorphism from an oriented graph G to an oriented graph H is a mapping $\varphi$ from the set of vertices of G to the set of vertices of H such that $\buildrel {\longrightarrow}\over {\varphi (u) \varphi (v)}$ is an arc in H whenever $\buildrel {\longrightarrow}\over {uv}$ is an arc in G. The oriented chromatic index of an oriented graph G
Pascal Ochem, Alexandre Pinlou, Éric Sopena   +2 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source