Results 51 to 60 of about 889,181 (180)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Prevention of moral weakness in cognitive psychology with emphasis on the theories of Piaget, Kalberg and Bandura [PDF]

اخلاق وحیانی
Moral weakness is one of the important issues of the psychology of ethics, which deals with why and how the gap between knowledge and moral action appears. In a comprehensive definition, this phenomenon can be considered as a conscious action against the
Mahdi Babolah zade, Masood Azarbayejani
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Beyond technology acceptance—a focused ethnography on the implementation, acceptance and use of new nursing technology in a German hospital

Frontiers in Digital Health
IntroductionHospitalised patients could benefit from the emergence of novel technologies for nursing care. There are numerous technical products available, but these rarely find their way into practice.
Ronny Klawunn, Urs-Vito Albrecht, Deliah Katzmarzyk, Marie-Luise Dierks   +3 more
doaj   +1 more source

The Effect of Air Pollution on Real-Estate Price in Tehran

برنامه‌ریزی و بودجه, 2022
This paper investigates the effect of air pollution on real-estate price in Tehran for the period (2013-14) and (2018-19). By combining microdata of real-estate transactions for more than 50,000 units that are traded multiple times during the period of ...
Parham Heidari Bahadori, Mohammad Hoseini   +1 more
doaj  

Developing the human resource strategies with the approach to Strategic Reference Points (SRP) (Case Study: The Civil Deputy of the Isfahan Municipality) [PDF]

Problems and Perspectives in Management, 2018
Codification and implementation of human resource strategy are practiced to make a bridge between policies and human resource methods, on the one hand, and strategic goals of the organization, on the other hand.
Mahdi Shahsiahi, Amirreza Naghsh
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The components of the military managment of the great prophet from the prespective of the Holy Quran and it’s implications of the contemporary world [PDF]

علوم و فنون نظامی
Objective: Today, the success of institutions and organizations largely depends on the efficiency and effectiveness of management. Management models that are connected to Islamic teachings will be very effective.
ahmad dehdar, Mohammad Amini Tehrani, ali aqa safari   +2 more
doaj   +1 more source

Oriented Measures

Journal of Mathematical Analysis and Applications, 1996
This paper deals with the range of vector-valued measures. The main purpose is to clarify the well-known Lyapunov convexity theorem for vector-valued measures on a real interval \([a,b]\). A vector measure \(\mu=(\mu_1,\dots,\mu_n)\) on \([a,b]\) is an oriented measure if it is nonatomic and if for each \(k\)-tuple \((1\leq k\leq n)\) of disjoint ...
R. Cerf, MARICONDA, CARLO
openaire   +2 more sources