Results 71 to 80 of about 4,421,314 (333)

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Comparative Study of the Wisdom behind Creation of Satan from the Perspective of Allameh Tabatabaii and Fakhr al-Razi [PDF]

open access: yesپژوهش‌های تفسیر تطبیقی, 2018
According to the Quranic teachings, the purpose of creation is worship to God and journey in the righteous path. However, it may seem that the creation of Satan who is never set on the right path and prevents human being from achieving his destination is
mohammad ali akhavian, Ali Badpa
doaj   +1 more source

Making the best of mixed-field orientation of polar molecules: A recipe for achieving adiabatic dynamics in an electrostatic field combined with laser pulses [PDF]

open access: yes, 2012
We have experimentally and theoretically investigated the mixed-field orientation of rotational-state-selected OCS molecules and we achieve strong degrees of alignment and orientation.
Bretislav Friedrich   +6 more
core   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Prevention of moral weakness in cognitive psychology with emphasis on the theories of Piaget, Kalberg and Bandura [PDF]

open access: yesاخلاق وحیانی
Moral weakness is one of the important issues of the psychology of ethics, which deals with why and how the gap between knowledge and moral action appears. In a comprehensive definition, this phenomenon can be considered as a conscious action against the
Mahdi Babolah zade, Masood Azarbayejani
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Beyond technology acceptance—a focused ethnography on the implementation, acceptance and use of new nursing technology in a German hospital

open access: yesFrontiers in Digital Health
IntroductionHospitalised patients could benefit from the emergence of novel technologies for nursing care. There are numerous technical products available, but these rarely find their way into practice.
Ronny Klawunn   +3 more
doaj   +1 more source

Orientation-Constrained Rectangular Layouts

open access: yes, 2009
We construct partitions of rectangles into smaller rectangles from an input consisting of a planar dual graph of the layout together with restrictions on the orientations of edges and junctions of the layout. Such an orientation-constrained layout, if it
C.-C. Liao   +9 more
core   +2 more sources

Oriented Measures

open access: yesJournal of Mathematical Analysis and Applications, 1996
This paper deals with the range of vector-valued measures. The main purpose is to clarify the well-known Lyapunov convexity theorem for vector-valued measures on a real interval \([a,b]\). A vector measure \(\mu=(\mu_1,\dots,\mu_n)\) on \([a,b]\) is an oriented measure if it is nonatomic and if for each \(k\)-tuple \((1\leq k\leq n)\) of disjoint ...
R. Cerf, MARICONDA, CARLO
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

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