Results 41 to 50 of about 219,767 (260)

Oriented total-coloring of oriented graphs

open access: yesDiscrete Mathematics
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bensmail, Julien   +6 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstruction of The Orientation Class of An Oriented Matroid

open access: yesEuropean Journal of Combinatorics, 1988
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Egalitarian Graph Orientations

open access: yesJournal of Graph Algorithms and Applications, 2017
Given an undirected graph, one can assign directions to each of the edges of the graph, thus orienting the graph. To be as egalitarian as possible, one may wish to find an orientation such that no vertex is unfairly hit with too many arcs directed into ...
Glencora Borradaile   +5 more
doaj   +1 more source

Task orientation and user‐oriented dialog design [PDF]

open access: yesInternational Journal of Human-Computer Interaction, 1991
Work psychologists have introduced a concept, in which dialog design is a part of task design. A set of criteria of user-oriented dialog design is presented. These criteria are consistently integrated into a control concept. Empirical investigations on some of these criteria are then described.
Ulich, E.   +4 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Internal market orientation and market‐oriented behaviours [PDF]

open access: yesJournal of Service Management, 2010
PurposeThe purpose of this empirical paper is to investigate internal marketing from a behavioural perspective. The impact of internal marketing behaviours, operationalised as an internal market orientation (IMO), on employees' marketing and other in‐role behaviours (IRB) were examined.Design/methodology/approachSurvey data measuring IMO, market ...
Lings, Ian, Greenley, Gordon
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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