Results 71 to 80 of about 5,605 (215)

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain [PDF]

, 2010
Background Cellular RNA polymerases (RNAPs) are complex molecular machines that combine catalysis with concerted conformational changes in the active center.
Robert OJ Weinzierl
core   +4 more sources

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Metabolic responses to Orientia tsutsugamushi infection in a mouse model. [PDF]

PLoS Neglected Tropical Diseases, 2015
Tsutsugamushi disease is an infectious disease transmitted to humans through the bite of the Orientia tsutsugamushi-infected chigger mite; however, host-pathogen interactions and the precise mechanisms of damage in O.
Jeeyoun Jung, Youngae Jung, Byoungchul Gill, Changhun Kim, Kyu-Jam Hwang, Young-Ran Ju, Hye-Ja Lee, Hyuk Chu, Geum-Sook Hwang   +8 more
doaj   +1 more source

Silent Threat: Multi‐Organ Failure in Neonatal Scrub Typhus Without Traditional Markers

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Scrub typhus, an acute zoonotic disease from Orientia tsutsugamushi, is uncommon in newborns and presents atypical symptoms. Untimely diagnosis and treatment can lead to a prolonged and potentially fatal course. Early diagnosis and treatment are essential for better patient outcomes.
Li Hu, Shuyan Li, Fangjian Gao, Shiguang Diao, Xiaoyan Liu, Jianwu Qiu   +5 more
wiley   +1 more source

The Effect of Climate Change on Emergence and Evolution of Zoonotic Diseases in Asia

Zoonoses and Public Health, Volume 72, Issue 7, Page 587-611, November 2025.
ABSTRACT As the climate of Asia changes under the influence of global warming, the incidence and spatial distribution of known zoonoses will evolve, and new zoonoses are expected to emerge as a result of greater exposure to organisms which currently occur only in wildlife.
Roger S. Morris, Masako Wada
wiley   +1 more source

Scrub typhus in the Northern Territory: exceeding the boundaries of Litchfield National Park [PDF]

, 2004
Scrub typhus is recognised as an important differential diagnosis of fever, rash and sepsis in patients with a history of travel to Litchfield National Park in the Top End of the Northern Territory.
Currie, Bart John, Raines, M, Ralph, Anna, Whelan, P I   +3 more
core   +1 more source

Variation in Small Mammal Species Composition and the Occurrence of Parasitic Mites in Two Landscapes in a Scrub Typhus Endemic Region of Western Yunnan Province, China

Ecology and Evolution, Volume 15, Issue 10, October 2025.
Yunnan Province, the most serious scrub typhus endemic areas in China, provides abundant ecological resources that sustain parasite and host populations. The distribution of vector‐borne diseases is driven by interactions between hosts, vectors and the environment, revealing critical ecological dynamics.
Yun‐Yan Luo, Jia‐Xiang Yin, Zong‐Ti Shao, Zeng‐Kan Liu, Shou‐Qin Yin, Jiang‐Li Lu, Jin‐Chun Li, Rong Wei, Alan Frederick Geater   +8 more
wiley   +1 more source

Causes of non-malarial fever in Laos: a prospective study [PDF]

, 2013
Background Because of reductions in the incidence of Plasmodium falciparum malaria in Laos, identifi cation of the causes of fever in people without malaria, and discussion of the best empirical treatment options, are urgently needed.
Castonguay-Vanier, Josée, Chansamouth, Vilada, Chanthongthip, Anisone, Dohnt, Michael, Douangdala, Phouvieng, Dubot-Pérès, Audrey, H Paris, Daniel, Hongvanthong, Bouasy, Inthalath, Saythong, Mayxay, Mayfong, Panyanouvong, Phonepasith, Phetsouvanh, Rattanaphone, Phommasone, Koukeo, Phonekeo, Darouny, Sibounheuang, Bountoy, Slesak, Günther, Souvannasing, Phoutthalavanh, Tangkhabuanbutra, Jarasporn, Tongyoo, Narongchai, Xayadeth, Sinakhone   +19 more
core  

Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand [PDF]

Infection, Genetics and Evolution, 2013
Orientia tsutsugamushi, an obligate intracellular bacterium closely related to the genus Rickettsia, is the causative agent of scrub typhus, a major cause of febrile illness in rural areas of Asia-Pacific region. Scrub typhus is transmitted by the bite of infected mites of the genus Leptotrombidium.
Wongprompitak, Patimaporn, Anukool, Wichittra, Wongsawat, Ekkarat, Silpasakorn, Saowalak, Duong, Veasna, Buchy, Philippe, Morand, Serge, Frutos, Roger, Ekpo, Pattama, Suputtamongkol, Yupin   +9 more
openaire   +2 more sources

The Endosymbiont Consortia of Two Cixiidae Planthoppers Reveal an Ancient Symbiosis With ‘Candidatus Mirabilia Symbiotica’

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
Many insects harbour ancient beneficial endosymbionts that produce essential nutrients. Two planthopper species from the Cixiidae family harbour different tripartite endosymbiont consortia, including a previously unknown and likely ancient Gammaproteobacterium in addition to Karelsulcia and Vidania.
Jessica Dittmer, Mathieu Mahillon, Christophe Debonneville, Franco Faoro, Xavier Foissac, Olivier Schumpp, Bessem Chouaia   +6 more
wiley   +1 more source