A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics. [PDF]
Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever.
Ahyong, Vida +4 more
core +2 more sources
The Effect of Climate Change on Emergence and Evolution of Zoonotic Diseases in Asia
ABSTRACT As the climate of Asia changes under the influence of global warming, the incidence and spatial distribution of known zoonoses will evolve, and new zoonoses are expected to emerge as a result of greater exposure to organisms which currently occur only in wildlife.
Roger S. Morris, Masako Wada
wiley +1 more source
Causes of non-malarial fever in Laos: a prospective study [PDF]
Background Because of reductions in the incidence of Plasmodium falciparum malaria in Laos, identifi cation of the causes of fever in people without malaria, and discussion of the best empirical treatment options, are urgently needed.
Castonguay-Vanier, Josée +19 more
core
Yunnan Province, the most serious scrub typhus endemic areas in China, provides abundant ecological resources that sustain parasite and host populations. The distribution of vector‐borne diseases is driven by interactions between hosts, vectors and the environment, revealing critical ecological dynamics.
Yun‐Yan Luo +8 more
wiley +1 more source
Many insects harbour ancient beneficial endosymbionts that produce essential nutrients. Two planthopper species from the Cixiidae family harbour different tripartite endosymbiont consortia, including a previously unknown and likely ancient Gammaproteobacterium in addition to Karelsulcia and Vidania.
Jessica Dittmer +6 more
wiley +1 more source
Scrub typhus in the Northern Territory: exceeding the boundaries of Litchfield National Park [PDF]
Scrub typhus is recognised as an important differential diagnosis of fever, rash and sepsis in patients with a history of travel to Litchfield National Park in the Top End of the Northern Territory.
Currie, Bart John +3 more
core +1 more source
Scrub typhus and the misconception of doxycycline resistance [PDF]
Scrub typhus, a neglected infectious disease caused by the obligate intracellular bacterium Orientia tsutsugamushi, is a major cause of fever across the Asia Pacific region with over a billion people at risk.
Day, NPJ +4 more
core +2 more sources
Current and Future Projection of Scrub Typhus Risk Related to Land Use Change in China
Abstract The widespread concern surrounding the enhanced spillover risk of infectious diseases due to dramatic global land use changes has sparked significant discussion. However, the specific implications of these changes on scrub typhus, a vector‐borne infectious disease facing increasing incidence and substantial expansion, remain unclear.
Ling Han +7 more
wiley +1 more source
Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand [PDF]
Orientia tsutsugamushi, an obligate intracellular bacterium closely related to the genus Rickettsia, is the causative agent of scrub typhus, a major cause of febrile illness in rural areas of Asia-Pacific region. Scrub typhus is transmitted by the bite of infected mites of the genus Leptotrombidium.
Wongprompitak, Patimaporn +9 more
openaire +2 more sources
CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection. [PDF]
Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, and 1 billion people are at
Guang Xu +7 more
doaj +1 more source

