Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Scrub typhus, caused by Orientia tsutsugamushi, is an acute febrile illness prevalent in Nepal with a wide spectrum of clinical presentations. Severe forms can lead to multiorgan dysfunction, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), septic shock, and rarely, acalculous cholecystitis.
Prabhat Kaphle +6 more
wiley +1 more source
Comparative evaluation of a point-of-care immunochromatographic test SNAP 4Dx with molecular detection tests for vector-borne canine pathogens in Hong Kong [PDF]
, 2011 There are no comprehensive studies on the performance of commonly used point-of-care diagnostic enzyme immunoassay for common arthropod-borne canine pathogens.
Chan, KH +7 more
core +1 more source
Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand [PDF]
Infection, Genetics and Evolution, 2013 Orientia tsutsugamushi, an obligate intracellular bacterium closely related to the genus Rickettsia, is the causative agent of scrub typhus, a major cause of febrile illness in rural areas of Asia-Pacific region. Scrub typhus is transmitted by the bite of infected mites of the genus Leptotrombidium.
Wongprompitak, Patimaporn +9 more
openaire +2 more sources
Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms
Drug Development Research, Volume 86, Issue 8, December 2025.ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu +5 more
wiley +1 more source
Silent Threat: Multi‐Organ Failure in Neonatal Scrub Typhus Without Traditional Markers
Clinical Case Reports, Volume 13, Issue 11, November 2025.ABSTRACT Scrub typhus, an acute zoonotic disease from Orientia tsutsugamushi, is uncommon in newborns and presents atypical symptoms. Untimely diagnosis and treatment can lead to a prolonged and potentially fatal course. Early diagnosis and treatment are essential for better patient outcomes.
Li Hu +5 more
wiley +1 more source
Metabolic responses to Orientia tsutsugamushi infection in a mouse model. [PDF]
PLoS Neglected Tropical Diseases, 2015 Tsutsugamushi disease is an infectious disease transmitted to humans through the bite of the Orientia tsutsugamushi-infected chigger mite; however, host-pathogen interactions and the precise mechanisms of damage in O.
Jeeyoun Jung +8 more
doaj +1 more source
Causes and outcomes of sepsis in southeast Asia: a multinational multicentre cross-sectional study [PDF]
, 2017 Background Improved understanding of pathogens that cause sepsis would aid management and antimicrobial selection. In this study, we aimed to identify the causative pathogens of sepsis in southeast Asia.
Southeast Asia, Infectious
core
The Effect of Climate Change on Emergence and Evolution of Zoonotic Diseases in Asia
Zoonoses and Public Health, Volume 72, Issue 7, Page 587-611, November 2025.ABSTRACT As the climate of Asia changes under the influence of global warming, the incidence and spatial distribution of known zoonoses will evolve, and new zoonoses are expected to emerge as a result of greater exposure to organisms which currently occur only in wildlife.
Roger S. Morris, Masako Wada
wiley +1 more source
Scrub typhus in the Northern Territory: exceeding the boundaries of Litchfield National Park [PDF]
, 2004 Scrub typhus is recognised as an important differential diagnosis of fever, rash and sepsis in patients with a history of travel to Litchfield National Park in the Top End of the Northern Territory.
Currie, Bart John +3 more
core +1 more source