Results 91 to 100 of about 2,792,977 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Rules of Origin as Commercial Policy Instruments. [PDF]
This paper examines the role of Rules of Origin as a commercial policy instrument which targets the input composition of imports. Using a three country, partial equilibrium structure, we demonstrate conditions under which the imposition of a binding Rule
Geoff Reed, Rod Falvey
core
Notes on the Origin of Jorge Luis Borges’ Bartolomé de Las Casas [PDF]
Литература двух АмерикThe 1935 short story collection A Universal History of Iniquity is a foundational stone in Jorge Luis Borges’ (1899–1986) remarkable narrative career.
Ricardo Monsalve
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Country-of-Origin Effect in International Trade [PDF]
Due to the globalization tendency, the companies are faced with the situation of responding to identical or increasingly similar needs that evolve in the same direction on different markets.
Claudia PETRUSCA, Andreea APETREI
core
Origin of Life: The Point of No Return
, 2020 Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important ...
Dimiter Kunnev
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2022 Sri Goki Flakam, 52 years old, is a resident of Taflap Mla, Chhaglagam Circle, Anjaw District. He narrates the story of the Flakam clan. According to him, the origin of Flakam is Kadam Kara. This means that the clans of Kadam Kara are native to the place
Johakso Manyu
core
Predictive modeling of Super El Niño through integrated local and global climate signals
Scientific ReportsRecent surges in extreme weather events underscore the critical need for advanced climate prediction models. Super El Niño (SE) events, characterized by unprecedented climatic and economic impacts, have intensified global concerns.
Chae-Hyun Yoon +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source