Results 251 to 260 of about 2,792,977 (316)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Application of Terahertz Technology in Food Safety: Rice Origin-Variety Classification Based on Spectral Analysis and Machine Learning. [PDF]

Foods
Ye D, Yuan X, Xu J, Wang C, Liu L, Liu H, Li J, Ren D, Li C.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Phenolic, Polysaccharide, and Color Variability in Chilean Commercial Chardonnay Wines: Influence of Closure Type, Geographic Origin, and Vintage. [PDF]

Foods
Peña-Neira A, Estay K, Jara C, Flores-Cabrales M, Ubeda C, Gil-I-Cortiella M.   +5 more
europepmc   +1 more source

Spatial organization and dynamics of genome replication: from forks to foci. [PDF]

Nucleic Acids Res
Pradhan SK, Arroyo M, Pabba MK, Leonhardt H, Cardoso MC.   +4 more
europepmc   +1 more source

Laparoscopic Local Resection via Duodenotomy for Cystic Heterotopic Pancreas Involving the Gastroduodenal Junction: A Case Report. [PDF]

Surg Case Rep
Gakuhara A, Teranishi R, Yamahira Y, Mikami N, Tsuchihashi K, Minami S, Fujii W, Koga C, Haraguchi N, Wakasa T, Kimura Y.   +10 more
europepmc   +1 more source

Anatomical patterns of pelvic venous reflux to the lower limbs. [PDF]

J Vasc Surg Venous Lymphat Disord
Storino J, Barros F, Cardoso Oliveira N.
europepmc   +1 more source