Results 171 to 180 of about 5,461,980 (349)

The Origin of Life: What Is the Question? [PDF]

Astrobiology, 2022
Malaterre C, Jeancolas C, Nghe P.
europepmc   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Editorial: Acetogens - from the origin of life to biotechnological applications. [PDF]

Front Microbiol, 2023
Basen M, Müller V.
europepmc   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Methane formation driven by light and heat prior to the origin of life and beyond. [PDF]

Nat Commun, 2023
Ernst L, Barayeu U, Hädeler J, Dick TP, Klatt JM, Keppler F, Rebelein JG.   +6 more
europepmc   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes. [PDF]

Proc Natl Acad Sci U S A, 2023
Babajanyan SG, Wolf YI, Khachatryan A, Allahverdyan A, Lopez-Garcia P, Koonin EV.   +5 more
europepmc   +1 more source

The origin of species : by means of natural selection, or, The preservation of favoured races in the struggle for life / by Charles Darwin.

, 1889
Charles Darwin
openalex   +2 more sources

Researches on the Origin and Life-Histories of the Least and Lowest Living Things [PDF]

, 1885
W. H. Dallinger
openalex   +1 more source

Exobiology: The NASA program [PDF]

The goal of NASA's Exobiology Program is to understand the origin, evolution, and distribution of life in the universe. To do this, the Exobiology Program seeks to provide a critical framework and some key research to allow NASA to bear the combined ...
Andersen, Dale, Harper, Lynn, Rummel, John D.   +2 more
core   +1 more source