Results 191 to 200 of about 174,381,677 (307)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

On the Origin of Life on Earth: The Nanozymes Hypothesis, and More. [PDF]

Research (Wash D C)
Jin Y.
europepmc   +1 more source

Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes. [PDF]

Proc Natl Acad Sci U S A, 2023
Babajanyan SG, Wolf YI, Khachatryan A, Allahverdyan A, Lopez-Garcia P, Koonin EV.   +5 more
europepmc   +1 more source

No Life on Life Origins [PDF]

Nature, 1967
openaire   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Characteristics of Langmuir monomolecular monolayers formed by the novel oil blends

Open Chemistry, 2023
Kamińska Wiktoria, Cichocki Wojciech, Baranowska Hanna Maria, Walkowiak Katarzyna, Kmiecik Dominik, Kowalczewski Przemysław Łukasz   +5 more
doaj   +1 more source

Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life. [PDF]

Life (Basel)
Shvetsova A, Fiore M.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Abiotic sources of fixed nitrogen sustained early ecosystems for several hundred million years after the origin of life. [PDF]

Sci Adv
Boden JS, Ni Z, Anderson RE, Stüeken EE.   +3 more
europepmc   +1 more source