Results 191 to 200 of about 858,173 (306)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Abiotic sources of fixed nitrogen sustained early ecosystems for several hundred million years after the origin of life. [PDF]

Sci Adv
Boden JS, Ni Z, Anderson RE, Stüeken EE.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Volcanic Island lightning prebiotic chemistry and the origin of life in the early Hadean eon. [PDF]

Nat Commun, 2023
Bada JL.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Bio-mediated CN cycling in serpentinites and the origin of life. [PDF]

Sci Rep
Tenuta S, Evans KA, Reddy SM, Tutolo BM, Rickard WDA, Saxey DW.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characteristics of Langmuir monomolecular monolayers formed by the novel oil blends

Open Chemistry, 2023
Kamińska Wiktoria, Cichocki Wojciech, Baranowska Hanna Maria, Walkowiak Katarzyna, Kmiecik Dominik, Kowalczewski Przemysław Łukasz   +5 more
doaj   +1 more source

Who Decides What Is Prebiotically Plausible? The Risks of Premature Constraints in Origin-of-Life Research. [PDF]

Life (Basel)
Eiby SHJ, Hassenkam T.
europepmc   +1 more source

RNA folding studies inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life. [PDF]

Sci Adv, 2023
Meyer MO, Yamagami R, Choi S, Keating CD, Bevilacqua PC.   +4 more
europepmc   +1 more source