Results 171 to 180 of about 858,173 (306)

Chemical evolution and the origin of life /

, 1971
Proceedings of the International conference on the origin of life"Sole distributors for the U.S.A. and Canada: American Elsevier Publishing Company ...
Ponnamperuma, Cyril Andrew,1923-1994(viaf)73918045, Buvet, René,1930-1992(viaf)9875554, International Conference on the Origin of Life3rd1970Pont-à-Mousson (France)   +2 more
core  

On the origin of life: an RNA-focused synthesis and narrative. [PDF]

RNA, 2023
Fine JL, Pearlman RE.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Editorial: Acetogens - from the origin of life to biotechnological applications. [PDF]

Front Microbiol, 2023
Basen M, Müller V.
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Redox chemistry of early Earth and the origin of life. [PDF]

Commun Chem
Moldogazieva NT, Terentiev AA, Mokhosoev IM, Astakhov DV.   +3 more
europepmc   +1 more source

Methane formation driven by light and heat prior to the origin of life and beyond. [PDF]

Nat Commun, 2023
Ernst L, Barayeu U, Hädeler J, Dick TP, Klatt JM, Keppler F, Rebelein JG.   +6 more
europepmc   +1 more source

Controversies on the origin of life.

International microbiology : the official journal of the Spanish Society for Microbiology, 2005
El estudio científico del origen de la vida se ha moldeado desde diferentes perspectivas con profundas raíces filosóficas e históricas. Ciertas hipótesis suponen una vida primordial basada en microorganismos anaeróbicos simples que usaban materiales orgánicos abióticos (origen heterotrófico), mientras que otras postulan que se inició con organizaciones
openaire   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source