Did minerals surfaces and meteorite components act as prebiotic catalysts for chemical evolution increasing molecular complexity toward the origin of life? [PDF]
It has already been known that both meteorite fragments and terrestrial minerals displayed iron catalyze inorganic and organic reactions leading to production of metalorganic entities (M4 material) which are able to perform catalytic activities typical
DEL GAUDIO, Rosanna
core
Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life. [PDF]
Life (Basel)Shvetsova A, Fiore M.
europepmc +1 more source
Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes. [PDF]
Proc Natl Acad Sci U S A, 2023 Babajanyan SG +5 more
europepmc +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
On the Origin of Life on Earth: The Nanozymes Hypothesis, and More. [PDF]
Research (Wash D C)Jin Y.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Can the Timing of the Origin of Life Be Inferred from Trends in the Growth of Organismal Complexity? [PDF]
Life (Basel)Juckett DA.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Abiotic sources of fixed nitrogen sustained early ecosystems for several hundred million years after the origin of life. [PDF]
Sci AdvBoden JS +3 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source