Results 181 to 190 of about 174,381,677 (307)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Redox chemistry of early Earth and the origin of life. [PDF]

Commun Chem
Moldogazieva NT, Terentiev AA, Mokhosoev IM, Astakhov DV.   +3 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Mafic-ultramafic igneous rocks as a source of reactive phosphorus for the origin of life. [PDF]

Nat Commun
Baidya AS, Walton CR, Kalita J, Szilas K, Viccaro M, Savage PS, Allison S, Nisbet EG, Schönbächler M, Mikhail S, Stüeken EE.   +10 more
europepmc   +1 more source

Editorial: Acetogens - from the origin of life to biotechnological applications. [PDF]

Front Microbiol, 2023
Basen M, Müller V.
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Replicating lipid micelles: a feasible precursor to the origin of life and the earliest appearance of genomes. [PDF]

Hum Genomics
Nebert DW, Liu Z, Vasiliou V.
europepmc   +1 more source

Methane formation driven by light and heat prior to the origin of life and beyond. [PDF]

Nat Commun, 2023
Ernst L, Barayeu U, Hädeler J, Dick TP, Klatt JM, Keppler F, Rebelein JG.   +6 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

An interdisciplinary effort to understand chemical organizations at the origin of life. [PDF]

iScience, 2023
Jeancolas C, Singh AY, Jain S, Krishna S, Nghe P.   +4 more
europepmc   +1 more source