A DNA fragment containing the origin of replication of the Escherichia coli chromosome.
Proceedings of the National Academy of Sciences of the United States of America, 1977 R. C. Marsh, A. Worcel
semanticscholar +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
T antigen binds to simian virus 40 DNA at the origin of replication.
Proceedings of the National Academy of Sciences of the United States of America, 1975 S. Reed +3 more
semanticscholar +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Origin of replication discovery for environmentally isolated <i>Pantoea</i> strain enables expression of heterologous proteins, pathways and products. [PDF]
iScienceCodik A +10 more
europepmc +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1979 D. Stalker, R. Kolter, D. Helinski
semanticscholar +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM. [PDF]
Nat Struct Mol BiolHenrikus SS +10 more
europepmc +1 more source
Structure and function of the adenovirus origin of replication.
Cell, 1984 D. Rawlins +4 more
semanticscholar +1 more source