Results 131 to 140 of about 14,422 (161)
Some of the next articles are maybe not open access.
Original antigen sin and COVID-19: implications for seasonal vaccination
Expert Opinion on Biological Therapy, 2022Original antigenic sin describes the phenomenon in which immunity against pathogens or antigens is shaped by the host's first exposure to a related pathogen or antigen.When primary immunity is boosted not by the homologous but by a cross-reacting vaccine, the newly formed antibodies may react better with the primary antigen than with the antigen ...
openaire +2 more sources
Age profile of immunity to influenza: Effect of original antigenic sin
Theoretical Population Biology, 2012When multiple infections are possible during an individual's lifetime, as with influenza, a host's history of infection and immunity will determine the result of future exposures. In turn, the suite of varying individual infection histories will shape the population level dynamics of the disease.
Kucharski, Adam J., Gog, Julia R.
openaire +2 more sources
Original Antigenic Sin in
ABSTRACTOriginal antigenic sin (OAS) describes the phenomenon in which prior exposure to an antigen weakens the adaptive antibody response to a subsequent heterologous infection. This phenomenon can diminish the effectiveness of immunity acquired through vaccination or previous infections.
Mingran Zhang, Junling Ma, Meili Li
openaire +2 more sources
Original antigenic sin. A confounding issue?
Developments in biologicals, 2004The 'Doctrine of Original Antigenic Sin', first phrased by Francis, Davenport & Hennessy in 1953, and followed up by occasional papers in the 1960s and 1970s, has lived a life in obscurity and negligence ever since it was postulated. From time to time, and with long intervals, papers on the subject appear.
openaire +1 more source
Immunoschismatics: Who is Guilty of Original Antigenic Sin?
1988Original antigenic sin was a term coined by Francis (1) to describe the tendency of a person to produce anti-influenza virus antibody specific for the original immunizing virus upon re-immunization with a related but antigenically distinct virus. In this paper, I will examine this process in terms of the cleavage, by antigen, of an intact immune system
openaire +1 more source
Disquisitions of Original Antigenic Sin. I. Evidence in man.
The Journal of experimental medicine, 1967When primary immunity is boosted not by the homologous but by a crossreacting vaccine, the newly formed antibodies react better with the primary antigen than with the antigen actually eliciting the response. This phenomenon bears the name of Original Antigenic Sin (1).
, Fazekas de St Groth, R G, Webster
openaire +1 more source
Using Blockchain Technology to Enhance the Traceability of Original Achievements
IEEE Transactions on Engineering Management, 2023Zhu, Peng, Hu Jian, Xiaotong Li
exaly