Results 51 to 60 of about 4,776,365 (127)

mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review highlights the transformative potential of mRNA cancer vaccines, leveraging technological advancements in nucleotide modification, lipid nanoparticle delivery, and AI‐driven neoantigen selection to enhance vaccine stability, immunogenicity, and personalization.
Bo Yang, Juan Liu, Yang Li, Xiaoxuan Liu
wiley   +1 more source

Original antigenic sin in virus infections

, 2017
Original antigenic sin (OAS) is an immunological phenomenon in which an initial antigen dominates the immune response toward subsequently encountered closely related antigens.
Partanen, Juulia
core  

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes [PDF]

, 2010
African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES).
Horn, David, McCulloch, Richard, Horn, David; id_orcid, David Horn, Richard McCulloch   +4 more
core   +1 more source

Harnessing Oxidized Alginate Microgels for Rapid and Self‐Assembling Dental Tissue Organogenesis In Vitro and In Vivo

Small Science, Volume 5, Issue 12, December 2025.
The system employs a high density human dental stem cells‐laden oxidized alginate‐based microgel with a "degrade‐to‐active" paradigm that mimics cellular condensation to enhance cell viability, achieve robust vascularization, and promote subsequent dental organogenesis, which is enabled by rapid degradation along with the elimination of residual ...
Chao Liang, Shuxuan Wu, Ziqi Huang, Zhenzhen Wu, Siyuan Chen, Feiming Li, Karrie Mei‐Yee Kiang, Gilberto Ka‐Kit Leung, Indong Jun, Hwan D. Kim, Ann‐Na Cho, Hee Jung Lee, Honghyun Park, Yiu Yan Leung, Seong Jun Kim, Seil Sohn, Haram Nah, Jae Seo Lee, Il Keun Kwon, Dong‐Nyoung Heo, Sang‐woo Lee, Zhaoming Wu, Sang Jin Lee   +22 more
wiley   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Juvenile Dermatomyositis Triggered by Influenza B: A Case Report on Viral‐Induced Autoimmunity

Pediatric Dermatology, Volume 42, Issue 6, Page 1255-1258, November/December 2025.
ABSTRACT A previously healthy 13‐year‐old boy developed juvenile dermatomyositis (JDM) shortly after a confirmed influenza B infection, presenting with progressive proximal muscle weakness and classic cutaneous findings. Laboratory tests revealed elevated muscle enzymes and myositis‐specific autoantibodies, supporting the diagnosis.
Santiago Dans‐Caballero, Miguel Juan‐Cencerrado, Carmen Mochón‐Jiménez, Rosa Roldán‐Molina, Verónica C. Pérez‐Guijo   +4 more
wiley   +1 more source

Original Sin - Analysing Its Mechanics and a proposed Remedy in a Simple Macroeconomic Model [PDF]

This paper analyses the problem of “original sin“ (the fact that the currency of an emerging market economy usually cannot be used to borrow abroad) in a simple thirdgeneration model of currency crises. The approach differs from alternative frameworks by
Axel Lindner
core  

The role of social contacts and original antigenic sin in shaping the age pattern of immunity to seasonal influenza. [PDF]

, 2012
Recent serological studies of seasonal influenza A in humans suggest a striking characteristic profile of immunity against age, which holds across different countries and against different subtypes of influenza.
Adam J. Kucharski (124315), Julia R. Gog (29872), Gog, Julia R, Adam J. Kucharski, Kucharski, Adam J, Adam J Kucharski, Julia R. Gog, Julia R Gog, Gog Julia R., Kucharski Adam J.   +9 more
core   +1 more source

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]

, 2013
Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Lucy Glover (24966), Sam Alsford, David Horn (24969), Alsford, Sam, Lucy Glover, Sam Alsford (24967), David Horn   +9 more
core   +1 more source

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.

, 1998
Some viruses, including human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in humans, and lymphocytic choriomeningitis virus (LCMV) in mice, are initially controlled by cytotoxic T lymphocytes (CTLs), but may subsequently escape through ...
Klenerman, Paul, Paul Klenerman, Zinkernagel, RM, Klenerman, P, Rolf M. Zinkernagel   +4 more
core   +1 more source