Results 1 to 10 of about 4,761,340 (218)

Immune History and Influenza Vaccine Effectiveness

Vaccines, 2018
The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic mismatch, but even when the match appears good, effectiveness can be surprisingly low.
Joseph A. Lewnard, Sarah Cobey
doaj   +1 more source

"Original Antigenic Sin" in SARS-CoV-2 Vaccination Followed by Infection. [PDF]

Cureus, 2022
Castillo-Aleman YM, Villegas-Valverde CA, Ventura-Carmenate Y, Suarez-Formigo GM, Bencomo-Hernandez AA.   +4 more
europepmc   +1 more source

COVID-19 pandemic and original antigenic sin: Future implications on vaccination policy

Journal of Public Health and Primary Care, 2023
Suraj Kapoor
doaj   +1 more source

Original Antigenic Sin: How Original? How Sinful? [PDF]

Cold Spring Harb Perspect Med, 2021
Yewdell JW, Santos JJS.
europepmc   +1 more source

Conformational bias in SARS-CoV-2 Spike CD4+ T-cell epitope dominance

Frontiers in Immunology
IntroductionEpitope-specific T cells provide significant long-lived protection afforded by adaptive immunity to SARS-CoV-2 spike. CD4+ T-cell epitope peptides that are generated by non-ATP-dependent antigen-processing proteases bind with modest ...
Samuel J. Landry, N. Kalaya Steede, Yali Tiomkin, Haley Smith, Ramgopal R. Mettu, Loren Gragert, Judith H. Aberle, Kevin J. Zwezdaryk, Crystal Zheng, Jay K. Kolls, Bronwyn M. Gunn, Amelie E. Murrell, Ivy V. Trinh, John S. Schieffelin, James E. Robinson, Elizabeth B. Norton   +15 more
doaj   +1 more source

SARS-CoV-2 vaccination washes away original antigenic sin. [PDF]

Trends Immunol, 2022
Pillai S.
europepmc   +1 more source

Immune Imprinting Identified in Phage-Display Antibody Libraries Derived from Early Wild-Type and Late Omicron COVID-19 Convalescents

Viruses
The rapid evolution of SARS-CoV-2, particularly the emergence of Omicron subvariants, has significantly reduced the efficacy of existing vaccines and monoclonal antibodies.
Boyang Li, Mengxuan Wang, Fang Huang, Wei Wu, Jiaxin Fan, Lu Yang, Yongbing Pan, Mifang Liang, Kai Duan   +8 more
doaj   +1 more source

Possible effect of the "original antigenic sin" in vaccination against new variants of SARS-CoV-2. [PDF]

Rev Clin Esp (Barc), 2022
Reina J.
europepmc   +2 more sources

Back to the Future: Immune Protection or Enhancement of Future Coronaviruses

Microorganisms
Before the emergence of SARS-CoV-1, MERS-CoV, and most recently, SARS-CoV-2, four other coronaviruses (the alpha coronaviruses NL63 and 229E and the beta coronaviruses OC43 and HKU1) had already been circulating in the human population. These circulating
Merit Bartels, Eric Sala Solé, Lotte M. Sauerschnig, Ger T. Rijkers   +3 more
doaj   +1 more source

SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations. [PDF]

Cell Rep, 2022
Anderson EM, Li SH, Awofolaju M, Eilola T, Goodwin E, Bolton MJ, Gouma S, Manzoni TB, Hicks P, Goel RR, Painter MM, Apostolidis SA, Mathew D, Dunbar D, Fiore D, Brock A, Weaver J, Millar JS, DerOhannessian S, UPenn COVID Processing Unit, Greenplate AR, Frank I, Rader DJ, Wherry EJ, Bates P, Hensley SE.   +25 more
europepmc   +1 more source