Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity [PDF]
The Journal of Clinical Investigation, 2023 Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19).
Muriel Aguilar-Bretones +3 more
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The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination [PDF]
Clinical Immunology Communications, 2021 Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the produced ...
Ger T. Rijkers, Frans J. van Overveld
doaj +5 more sources
SARS-CoV-2 vaccination in the context of original antigenic sin [PDF]
Human Vaccines & Immunotherapeutics, 2022 Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the ...
Marek Petráš, Ivana Králová Lesná
doaj +6 more sources
Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? [PDF]
Human Vaccines & Immunotherapeutics, 2021 India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge.
Vipin M. Vashishtha
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Original Antigenic Sin and Respiratory Syncytial Virus Vaccines [PDF]
Vaccines, 2019 The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of ...
Ralph A. Tripp, Ultan F. Power
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Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants [PDF]
MedCommOriginal antigenic sin (OAS), or immune imprinting, triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ancestral (WT) strain vaccine, or infection, has led to weakened neutralizing antibody response against Omicron variant like BA ...
Guangxu Zhang +15 more
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Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19 [PDF]
mSphere, 2021 The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing
Eric L. Brown, Heather T. Essigmann
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The Wages of Original Antigenic Sin [PDF]
Emerging Infectious Diseases, 2010 David M. Morens +2 more
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Understanding original antigenic sin in influenza with a dynamical system. [PDF]
PLoS ONE, 2011 Original antigenic sin is the phenomenon in which prior exposure to an antigen leads to a subsequent suboptimal immune response to a related antigen. Immune memory normally allows for an improved and rapid response to antigens previously seen and is the ...
Keyao Pan
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Original antigenic sin: not so sinful after all. [PDF]
Trends Immunol, 2023 'Original antigenic sin' predicts that antibody responses to secondary infections with escape mutants are dominated by specificities to the original pathogen. Using transgenic mice in which antibodies are tagged based on cellular origins and kinetics, Schiepers et al.
Baumgarth N.
europepmc +5 more sources