Results 11 to 20 of about 14,580 (242)
The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination [PDF]
Clinical Immunology Communications, 2021 Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the produced ...
Ger T. Rijkers, Frans J. van Overveld
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Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19 [PDF]
mSphere, 2021 The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing
Eric L. Brown, Heather T. Essigmann
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Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies. [PDF]
Proc Natl Acad Sci U S A, 2020 SignificanceHumans are typically infected with influenza viruses in childhood and then continuously exposed to antigenically distinct influenza virus strains throughout life. Antibody responses elicited by initial influenza virus infections can be boosted upon subsequent exposures with antigenically drifted influenza virus strains.
Arevalo CP +10 more
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From Original Antigenic Sin to the Universal Influenza Virus Vaccine. [PDF]
Trends Immunol, 2018 Antibody responses are essential for protection against influenza virus infection. Humans are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that immune history influences the magnitude and quality of the antibody response.
Henry C, Palm AE, Krammer F, Wilson PC.
europepmc +6 more sources
The Doctrine of Original Antigenic Sin: Separating Good From Evil. [PDF]
J Infect Dis, 2017 The term "original antigenic sin" was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza ...
Monto AS +3 more
europepmc +6 more sources
Strategies to alleviate original antigenic sin responses to influenza viruses. [PDF]
Proc Natl Acad Sci U S A, 2012 Original antigenic sin is a phenomenon wherein sequential exposure to closely related influenza virus variants reduces antibody (Ab) response to novel antigenic determinants in the second strain and, consequently, impairs the development of immune memory.
Kim JH, Davis WG, Sambhara S, Jacob J.
europepmc +6 more sources
Original antigenic sin in dengue - Hoskins effect
APIK Journal of Internal Medicine, 2023 Dengue is a mosquito-borne viral infection found in tropical and subtropical climates worldwide, mostly in urban and semiurban areas. The virus responsible for causing dengue is called dengue virus. There are four dengue virus serotypes, implying that it
Vasantha Kamath, Nisha Davy Olakkengi
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SARS-CoV-2 vaccination washes away original antigenic sin. [PDF]
Trends Immunol, 2022 According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also
Pillai S.
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Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really “Sinful”? [PDF]
Viruses, 2023 The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Tal Einav +5 more
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Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS [PDF]
Frontiers in Immunology, 2020 Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical
Walter Fierz, Brigitte Walz
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