SARS-CoV-2 vaccination in the context of original antigenic sin [PDF]
Human Vaccines & Immunotherapeutics, 2022 Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the ...
Marek Petráš, Ivana Králová Lesná
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Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? [PDF]
Human Vaccines & Immunotherapeutics, 2021 India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge.
Vipin M. Vashishtha
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Original Antigenic Sin and Respiratory Syncytial Virus Vaccines [PDF]
Vaccines, 2019 The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of ...
Ralph A. Tripp, Ultan F. Power
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Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading [PDF]
Frontiers in Immunology, 2017 Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A ...
Sandra M. McLachlan, Basil Rapoport
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Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity [PDF]
The Journal of Clinical Investigation, 2023 Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19).
Muriel Aguilar-Bretones +3 more
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The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination [PDF]
Clinical Immunology Communications, 2021 Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the produced ...
Ger T. Rijkers, Frans J. van Overveld
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Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19 [PDF]
mSphere, 2021 The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing
Eric L. Brown, Heather T. Essigmann
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Understanding original antigenic sin in influenza with a dynamical system. [PDF]
PLoS ONE, 2011 Original antigenic sin is the phenomenon in which prior exposure to an antigen leads to a subsequent suboptimal immune response to a related antigen. Immune memory normally allows for an improved and rapid response to antigens previously seen and is the ...
Keyao Pan
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Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really “Sinful”? [PDF]
Viruses, 2023 The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Tal Einav +5 more
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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin [PDF]
Nature CommunicationsSeveral studies have suggested the imprinting of SARS-CoV-2 immunity by original immune challenge without addressing the formation of the de novo response to successive antigen exposures.
Jernej Pušnik +6 more
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