Results 11 to 20 of about 4,187 (224)
DISQUISITIONS ON ORIGINAL ANTIGENIC SIN [PDF]
Journal of Experimental Medicine, 1966 Experiments in rabbits were designed to test the two unproven assumptions of the hypothesis proposed in the companion paper (1): that Original Antigenic Sin is fundamentally a restricted anamnestic response, and that there exists a trapping mechanism capable of deflecting antigen from one kind of cell and guiding it to another.
Webster R G
exaly +7 more sources
Original antigenic sin in dengue revisited. [PDF]
Proc Natl Acad Sci U S A, 2013 The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or pathogenic.
Zompi S, Harris E.
europepmc +6 more sources
Original Antigenic Sin and Pandemic (H1N1) 2009 [PDF]
Emerging Infectious Diseases, 2010 To the Editor: While pandemic (H1N1) 2009 was in its earliest stages, age distribution data indicated surprisingly few cases among persons >65 years of age. The initial assumption was that few persons >65 years of age had yet to be exposed. However, as more data became available from Mexico, Australia, and the United States, the age distribution ...
Amesh A. Adalja, D.A. Henderson
doaj +4 more sources
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS [PDF]
Frontiers in Immunology, 2020 Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical
Walter Fierz, Brigitte Walz
doaj +4 more sources
Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading [PDF]
Frontiers in Immunology, 2017 Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A ...
Sandra M. McLachlan, Basil Rapoport
doaj +4 more sources
Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses. [PDF]
PLoS Pathogens, 2016 Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response.
Susanne L Linderman, Scott E Hensley
doaj +4 more sources
An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection [PDF]
J Virol, 2011 ABSTRACTThe evolution of dengue viruses has resulted in four antigenically similar yet distinct serotypes. Infection with one serotype likely elicits lifelong immunity to that serotype, but generally not against the other three. Secondary or sequential infections are common, as multiple viral serotypes frequently cocirculate. Dengue infection, although
Midgley C +15 more
europepmc +13 more sources
Original antigenic sin: A comprehensive review
Journal of Autoimmunity, 2017 The concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed.
Diana M Monsalve +2 more
exaly +5 more sources
SARS-CoV-2 vaccination washes away original antigenic sin. [PDF]
Trends Immunol, 2022 According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also
Pillai S.
europepmc +5 more sources
Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin [PDF]
Nature CommunicationsSeveral studies have suggested the imprinting of SARS-CoV-2 immunity by original immune challenge without addressing the formation of the de novo response to successive antigen exposures.
Jernej Pušnik +6 more
doaj +4 more sources