International Journal of Infectious Diseases, 2018 A 27-year-old pregnant woman who was positive for anti-cytomegalovirus (CMV) antibodies gave birth to a congenitally CMV-infected neonate at 40 weeks of gestation.
Tetsuo Koshizuka +5 more
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The role of social contacts and original antigenic sin in shaping the age pattern of immunity to seasonal influenza. [PDF]
PLoS Computational Biology, 2012 Recent serological studies of seasonal influenza A in humans suggest a striking characteristic profile of immunity against age, which holds across different countries and against different subtypes of influenza.
Adam J Kucharski, Julia R Gog
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Inactivated COVID-19 vaccines: potential concerns of antibody-dependent enhancement and original antigenic sin [PDF]
Immunology Letters, 2023 Inactivated vaccine is one of the platforms employed in COVID-19 vaccines. Inactivated vaccines have been associated with concerns of antibody-dependent enhancement (ADE) and original antigenic sin (OAS), which are related to non-neutralising or poorly ...
Philip H Li, Andy Ka Chun Kan
exaly +3 more sources
Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection [PDF]
Infectious Diseases & Immunity. Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections.
Miao Wang +4 more
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Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS [PDF]
Frontiers in Immunology, 2020 Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical
Walter Fierz, Brigitte Walz
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Innate immunity and training to subvert original antigenic sin by the humoral immune response [PDF]
eLifeOriginally defined in the context of influenza vaccines by Thomas Francis Jr. in the late 1950s, original antigenic sin (OAS) refers to the tendency of the immune system to preferentially recall B cell memory against primary antigen after secondary ...
Faez Amokrane Nait Mohamed +1 more
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Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants [PDF]
MedCommOriginal antigenic sin (OAS), or immune imprinting, triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ancestral (WT) strain vaccine, or infection, has led to weakened neutralizing antibody response against Omicron variant like BA ...
Guangxu Zhang +15 more
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Evaluating Memory B Cell Cross-Reactivity Between Ancestral and Future SARS-CoV-2 Variants—Evidence for Original Antigenic Sin [PDF]
VaccinesBackground: Despite the circulation of evolutionarily related cold-causing coronaviruses (CCCs) in the pre-COVID era, most individuals lacked pre-existing serum IgG and/or class-switched memory B cell (Bmem) reactivity for the SARS-CoV-2 Spike (S ...
Lingling Yao +3 more
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Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients [PDF]
Journal of Infectious Diseases, 2019 A human cytomegalovirus (HCMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in HCMV-infected individuals (HCMV+).
Paul Griffiths, Ilona Baraniak
exaly +4 more sources
Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses. [PDF]
PLoS Pathogens, 2016 Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response.
Susanne L Linderman, Scott E Hensley
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