The Doctrine of Original Antigenic Sin: Separating Good From Evil. [PDF]
J Infect Dis, 2017 The term "original antigenic sin" was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza ...
Monto AS +3 more
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Strategies to alleviate original antigenic sin responses to influenza viruses. [PDF]
Proc Natl Acad Sci U S A, 2012 Original antigenic sin is a phenomenon wherein sequential exposure to closely related influenza virus variants reduces antibody (Ab) response to novel antigenic determinants in the second strain and, consequently, impairs the development of immune memory.
Kim JH, Davis WG, Sambhara S, Jacob J.
europepmc +5 more sources
Original antigenic sin responses to influenza viruses. [PDF]
J Immunol, 2009 Abstract Most immune responses follow Burnet’s rule in that Ag recruits specific lymphocytes from a large repertoire and induces them to proliferate and differentiate into effector cells. However, the phenomenon of “original antigenic sin” stands out as a paradox to Burnet’s rule of B cell engagement.
Kim JH, Skountzou I, Compans R, Jacob J.
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Inactivated COVID-19 vaccines: potential concerns of antibody-dependent enhancement and original antigenic sin [PDF]
Immunology Letters, 2023 Andy Ka Chun Kan, Philip H Li
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From Original Antigenic Sin to the Universal Influenza Virus Vaccine [PDF]
Trends in Immunology, 2018 Antibody responses are essential for protection against influenza virus infection. Humans are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that immune history influences the magnitude and quality of the antibody response.
Carole Henry +2 more
exaly +5 more sources
Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin [PDF]
mBio, 2017 Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran +9 more
doaj +4 more sources
Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity. [PDF]
Immune Netw, 2016 The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This
Park MS, Kim JI, Park S, Lee I, Park MS.
europepmc +5 more sources
Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients [PDF]
Journal of Infectious Diseases, 2019 Ilona Baraniak +2 more
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Original Antigenic Sin: How Original? How Sinful? [PDF]
Cold Spring Harb Perspect Med, 2021 We review the phenomenon of "original antigenic sin" (OAS) in antibody responses to influenza A virus (IAV) infection or vaccination. OAS refers to the preferential induction of antibodies with higher affinity to priming versus boosting immunogens. We emphasize its mechanistic basis and origins in the basic immunobiology of B-cell responses to myriad ...
Yewdell JW, Santos JJS.
europepmc +4 more sources
COVID-19 pandemic and original antigenic sin: Future implications on vaccination policy
Journal of Public Health and Primary Care, 2023 Suraj Kapoor
doaj +3 more sources