"Original Antigenic Sin" in SARS-CoV-2 Vaccination Followed by Infection. [PDF]
Cureus, 2022 Although the "original antigenic sin" (OAS) effects have been predicted against new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), only a few pieces of evidence are available regarding its impact on the safety and effectiveness of coronavirus disease 2019 (COVID-19) vaccines.
Castillo-Aleman YM +4 more
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Innate immunity and training to subvert original antigenic sin by the humoral immune response [PDF]
eLifeOriginally defined in the context of influenza vaccines by Thomas Francis Jr. in the late 1950s, original antigenic sin (OAS) refers to the tendency of the immune system to preferentially recall B cell memory against primary antigen after secondary ...
Faez Amokrane Nait Mohamed +1 more
doaj +2 more sources
DISQUISITIONS ON ORIGINAL ANTIGENIC SIN [PDF]
The Journal of Experimental Medicine, 1966 Experiments in rabbits were designed to test the two unproven assumptions of the hypothesis proposed in the companion paper (1): that Original Antigenic Sin is fundamentally a restricted anamnestic response, and that there exists a trapping mechanism capable of deflecting antigen from one kind of cell and guiding it to another.
S. Fazekas de St.Groth, R. G. Webster
openaire +4 more sources
Original antigenic sin: A comprehensive review
Journal of Autoimmunity, 2017 The concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed.
Vatti A. +5 more
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Original antigenic sin in dengue revisited. [PDF]
Proc Natl Acad Sci U S A, 2013 The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or pathogenic.
Zompi S, Harris E.
europepmc +4 more sources
Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants [PDF]
MedCommOriginal antigenic sin (OAS), or immune imprinting, triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ancestral (WT) strain vaccine, or infection, has led to weakened neutralizing antibody response against Omicron variant like BA ...
Guangxu Zhang +15 more
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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin [PDF]
Nature CommunicationsSeveral studies have suggested the imprinting of SARS-CoV-2 immunity by original immune challenge without addressing the formation of the de novo response to successive antigen exposures.
Jernej Pušnik +6 more
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Original antigenic sin responses to influenza viruses. [PDF]
J Immunol, 2009 Abstract Most immune responses follow Burnet’s rule in that Ag recruits specific lymphocytes from a large repertoire and induces them to proliferate and differentiate into effector cells. However, the phenomenon of “original antigenic sin” stands out as a paradox to Burnet’s rule of B cell engagement.
Kim JH, Skountzou I, Compans R, Jacob J.
europepmc +4 more sources
Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection. [PDF]
PLoS ONE, 2021 BackgroundThe effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood.ObjectivesWe sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike ...
Stacey A Lapp +9 more
doaj +2 more sources
A speed limit on serial strain replacement from original antigenic sin. [PDF]
Proc Natl Acad Sci U S AAbstractMany pathogens evolve to escape immunity, yet it remains difficult to predict whether immune pressure will lead to diversification, serial replacement of one variant by another, or more complex patterns. Pathogen strain dynamics are mediated by cross-protective immunity, whereby exposure to one strain partially protects against infection by ...
McGough L, Cobey S.
europepmc +5 more sources