Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity. [PDF]
Immune Netw, 2016 The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This
Park MS, Kim JI, Park S, Lee I, Park MS.
europepmc +4 more sources
Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses. [PDF]
PLoS Pathogens, 2016 Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response.
Susanne L Linderman, Scott E Hensley
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The role of social contacts and original antigenic sin in shaping the age pattern of immunity to seasonal influenza. [PDF]
PLoS Computational Biology, 2012 Recent serological studies of seasonal influenza A in humans suggest a striking characteristic profile of immunity against age, which holds across different countries and against different subtypes of influenza.
Adam J Kucharski, Julia R Gog
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Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin [PDF]
mBio, 2017 Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran +9 more
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An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection [PDF]
J Virol, 2011 ABSTRACTThe evolution of dengue viruses has resulted in four antigenically similar yet distinct serotypes. Infection with one serotype likely elicits lifelong immunity to that serotype, but generally not against the other three. Secondary or sequential infections are common, as multiple viral serotypes frequently cocirculate. Dengue infection, although
Midgley C +15 more
europepmc +9 more sources
COVID-19 pandemic and original antigenic sin: Future implications on vaccination policy
Journal of Public Health and Primary Care, 2023 Suraj Kapoor
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Inactivated COVID-19 vaccines: potential concerns of antibody-dependent enhancement and original antigenic sin. [PDF]
Immunol Lett, 2023 Kan AKC, Li PH.
europepmc +2 more sources
Original antigenic sin: A potential double-edged effect for vaccine improvement
Biomedicine & PharmacotherapyOriginal antigenic sin (OAS) influences the immune response to subsequent infections with related variants following initial pathogen exposure. This phenomenon is characterized by cross-reactivity, which, although it may worsen infections, also provides a degree of protection against immune evasion caused by variations.
Xuan Ding +5 more
openaire +4 more sources
Age-specific mortality during the 1918 influenza pandemic: unravelling the mystery of high young adult mortality. [PDF]
, 2013 The worldwide spread of a novel influenza A (H1N1) virus in 2009 showed that influenza remains a significant health threat, even for individuals in the prime of life.
Bourbeau, Robert +6 more
core +20 more sources
Earliest infections predict the age distribution of seasonal influenza A cases
eLife, 2020 Seasonal variation in the age distribution of influenza A cases suggests that factors other than age shape susceptibility to medically attended infection.
Philip Arevalo +3 more
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