Results 31 to 40 of about 4,187 (224)

Original antigenic sin in dengue - Hoskins effect

APIK Journal of Internal Medicine, 2023
Dengue is a mosquito-borne viral infection found in tropical and subtropical climates worldwide, mostly in urban and semiurban areas. The virus responsible for causing dengue is called dengue virus. There are four dengue virus serotypes, implying that it
Vasantha Kamath, Nisha Davy Olakkengi
doaj   +2 more sources

Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really “Sinful”? [PDF]

Viruses, 2023
The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Tal Einav, Martina Kosikova, Peter Radvak, Yuan-Chia Kuo, Hyung Joon Kwon, Hang Xie   +5 more
doaj   +2 more sources

"Original Antigenic Sin" in SARS-CoV-2 Vaccination Followed by Infection. [PDF]

Cureus, 2022
Although the "original antigenic sin" (OAS) effects have been predicted against new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), only a few pieces of evidence are available regarding its impact on the safety and effectiveness of coronavirus disease 2019 (COVID-19) vaccines.
Castillo-Aleman YM, Villegas-Valverde CA, Ventura-Carmenate Y, Suarez-Formigo GM, Bencomo-Hernandez AA.   +4 more
europepmc   +3 more sources

Innate immunity and training to subvert original antigenic sin by the humoral immune response [PDF]

eLife
Originally defined in the context of influenza vaccines by Thomas Francis Jr. in the late 1950s, original antigenic sin (OAS) refers to the tendency of the immune system to preferentially recall B cell memory against primary antigen after secondary ...
Faez Amokrane Nait Mohamed, Daniel Lingwood   +1 more
doaj   +2 more sources

Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection. [PDF]

PLoS ONE, 2021
BackgroundThe effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood.ObjectivesWe sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike ...
Stacey A Lapp, Venkata Viswanadh Edara, Austin Lu, Lilin Lai, Laila Hussaini, Ann Chahroudi, Larry J Anderson, Mehul S Suthar, Evan J Anderson, Christina A Rostad   +9 more
doaj   +2 more sources

Signatures of Original Antigenic Sin or protection following coronavirus imprinting in Syrian hamsters challenged with SARS-CoV-2 or variants [PDF]

, 2023
Francis M, Jansen E, Yourkowski A, Selim A, Swan C, MacPhee B, Thivierge B, Buchanan R, Lavender K, Darbellay J, Rogers M, Lew J, Gerdts V, Falzarano D, Skowronski D, Sjaarda C, Kelvin A.   +16 more
europepmc   +2 more sources

Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin. [PDF]

Cell Mol Immunol
Ling Z, Zheng Z, Xu L, Yi C, Dong X, Gu X, Sun X, Wu B, Sun B, Zhou W.   +9 more
europepmc   +3 more sources

Bivalent COVID-19 Vaccines: Can the Original Antigenic Sin Be Forgiven? [PDF]

Journal of Infectious Diseases, 2023
Joel N Blankson, Blankson Joel N
exaly   +2 more sources

Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin. [PDF]

Life (Basel), 2021
Focosi D, Genoni A, Lucenteforte E, Tillati S, Tamborini A, Spezia PG, Azzi L, Baj A, Maggi F.   +8 more
europepmc   +3 more sources

SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations [PDF]

Cell Reports, 2022
Elizabeth M Anderson, Sigrid Gouma, Mark M Painter   +2 more
exaly   +2 more sources