Frontiers in Immunology, 2023 The first exposure to influenza is presumed to shape the B-cell antibody repertoire, leading to preferential enhancement of the initially formed responses during subsequent exposure to viral variants.
Petra Mooij +23 more
doaj +1 more source
CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]
, 2018 Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core +2 more sources
Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields
Viruses, 2023 Mutations and the glycosylation of epitopes can convert immunogenic epitopes into non-immunogenic ones via natural selection or evolutionary pressure, thereby decreasing their sensitivity to neutralizing antibodies.
Leili Baghaie +5 more
doaj +1 more source
Vaccines, 2018 The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts.
Ewan P. Plant +5 more
doaj +1 more source
HLA, Immune Response, and Susceptibility to COVID-19
Frontiers in Immunology, 2021 The severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2) that appeared in December 2019 has precipitated the global pandemic Coronavirus Disease 2019 (COVID-19).
Fataneh Tavasolian +9 more
doaj +1 more source
Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]
, 2009 BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P +11 more
core +1 more source
Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers [PDF]
, 2018 This work was supported by the Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), grants E-26/202.974/2015 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grants 229755/2013-5, Brazil.
A Chakrabarti +69 more
core +9 more sources
Sequence Space Localization in the Immune System Response to Vaccination and Disease
, 2003 We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can \emph{increase} susceptibility to ...
Deem, Michael W., Lee, Ha Youn
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Modelling original antigenic sin in dengue viral infection
Mathematical Medicine and Biology: A Journal of the IMA, 2017 Cross-reactive T cell responses induced by a primary dengue virus infection may contribute to increased disease severity following heterologous infections with a different virus serotype in a phenomenon known as the original antigenic sin. In this study, we developed and analyzed in-host models of T cell responses to primary and secondary dengue virus ...
Ryan, Nikin-Beers, Stanca M, Ciupe
openaire +2 more sources
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Cell Reports Medicine, 2021 Summary: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy.
Daniel J. Sheward +12 more
doaj +1 more source