Results 101 to 110 of about 10,223,431 (298)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
ORIGINAL ARTICLE: Will An Additional Observer Enhance Adenoma Detection During Colonoscopy? [PDF]
Journal of Krishna Institute of Medical Sciences University, 2012 Background: Due to varied level of experience, the detection rate of adenoma on colonoscopy is different. In presence of both fellows and attending the incidence rates of adenoma are shown to increase in a small study reported by Rogart et al [4].
Kevin D Mullen +5 more
doaj
Original article Perception of purpose and parental involvement in competitive youth sport
Health Psychology Report, 2015 Background Because of the various demanding investments, parents develop various expectations regarding their children’s sport experience. The purposes of this study were twofold: (a) to determine whether there is a discrepancy between parents and ...
Ashley Marsh +3 more
doaj +1 more source
Original article. Nurse-controlled analgesia for postoperative pain in pediatric patients: effects on nurses’ attitudes and patient care [PDF]
, 2014 Suwannee Suraseranivongse +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Review of: G. Whitney Azoy. Buzkashi: Game and Power in Afghanistan. Philadelphia: University of Pennsylvania Press [PDF]
, 2002 This is a preprint (author's original) version of the article published in Iranian Studies Special Issue: Sports and Games: 421-4. The final version of the article can be found at http://www.jstor.org/stable/4311481. The version made available in Digital
Lindholm, Charles
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source