Results 91 to 100 of about 79,683,097 (270)

Distinctive Geometrical Traits of Proximal Femur Fractures-Original Article and Review of Literature. [PDF]

open access: yesMedicina (Kaunas), 2023
Vlachos C   +10 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Marble Statue of a Youth

open access: yes
Overall view; Marble statue of a youth. Roman copy, 1st century AD, of a Greek original of about 460 BC. This naked youth is a marble copy of a Greek bronze statue, and illustrates characteristic traits of bronze work translated into marble.
unknown (Ancient Roman sculptor, after Greek original)
core  

Clinical Profile and Management of Peritonsillar Abscess in a Sub Saharan Africa [PDF]

open access: yes, 2020
Background: Peritonsillar abscess is a common pathology that presents to an otolaryngologist with poor documentation especially in developing countries. The aim of this study was to describe the clinical profile and management of peritonsillar abscess in
Adegbiji, Waheed Atilade   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Marble portrait bust of Perikles

open access: yes
Overall view showing the right side; Roman, 2nd century AD copy of a lost Greek original of around 440-430 BC. This is a Roman copy of an original portrait which was perhaps created in Perikles' own day, or shortly after his death.
unknown (Ancient Roman sculptor, after Greek original)
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Original Newspaper Collection

open access: yes
The Original Newspaper Collection has a growing collection of newspaper titles. The majority of the newspapers date from the 19th and 20th centuries; however, a select few date back to the 18th century. Many of the newspapers were published in Baltimore,
Original Newspaper Collection
core  

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